Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

HIstology > Epithelium: Apical Differentiations and CAM > Flashcards

Epithelium: Apical Differentiations and CAM Flashcards

1
Q

Kinocilium

A

a type of primary cilia that is part of the organ or corti in the inner ear

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What lines the oviduct?

A

ciliated epithelial cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Clijum is made up of..

A

microtubules

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

microvilli are made up of

A

microfiliments

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

sterocillium are made up of

A

microfiliments

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Paracellular pathway

A

between cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

transcellular pathway

A

through cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

basal lamina is made up off

A

type 4 collagen +laminin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

the reticular lamina is made up of

A

collagens, fibronectin, proteoglycans

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Cadherins have how many calcium domains?

A

4

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What sequence on the Cadherin facilitates cis-homophillic dimer formation

A

HVA (histadine-valine-alanine)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What are the three actin binding proteins on Cadherins?

A

Vinculin, formin-1, alpha actinin (catinins)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Name calcium dependent CAM?

A

Cadherin and Selectin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Name Calcium independent CAM?

A

IgSF and Integrins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

E-cadherin is found in..

A

epithelia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

N-cadherin is found in…

A

CNS, lens of the eye, cardiac and skeletal muscle

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

P-Cadherin is found in…

A

placenta (tropoblast)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Removal of Calcium disrupts…

A

tissue cohesiveness

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

What CAMS bind to F-Actin?

A

Cadherins and Integrins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

What are the actin binding proteins for integrins?

A

Vinculin, talin, alpha actinin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

beta catinin is also seen as a

A

transcriptional cofactor….colorectal carcingenisis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

What are the three distinct apical differentiations?

A

Cilia
Microvilli
Sterocilia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Selectins

A

Carbohydrate recognizing domain

24
Q

What alters the carbohydrate recognizing domain in Selectins?

A

Calcium bound at the sides of the CRD regulates the conformation of the domain and its ability to bind carbohydrates

25
What CAMs play a part in homing?
Selectins | Integrins attached to ICAM
26
Selectins mediate interactions between what...
leukocytes and endothelial cells or blood platlets | intiate interactions between leukoctes from circulation to the sites of tissue inflammation
27
E-selectin
Activated endothelial cells (blood vessels)
28
L-selectin
leukocytes
29
P-selectin
platelets and activated endothelial cells lining blood vessels (stored inc ytoplasmic vesicles in endothelial cells) **on surface leukocytes have sialyl lewis-x antigen(olgiosaccride ligand for P-selectin) slow down leukocytes
30
Homing (describe process)
1. Selectins mediate initial adhesion of leukocytes to endothelial cells 2. formation of more stable adhesions in which integrins (on surface of leukoytes) bind to intracellular adhesion molecules (ICAMS, IgSF) 3. The firmly attached leukocytes penetrate hte walls of cpaillaries and enter the tissue by migrating between endothelial cells (transcellular pathway) Transendothelial migration
31
What are the main adhesion proteins holding peithelial cells together?
Cadherins | Sheet arrangement
32
Which part of the Cadherin interacts wiht F-actin
The cytoplasmic Tail | through catinins
33
What catinin directly binds to Cadherin
beta
34
What catinin directly binds to actin
alpha
35
Selectins have how many extra cellular domains?
three
36
What are the three main domains of Selectins?
1. Carbohydrate recognition domain (olgiosaccrides when attached to protien glycoprotein.. when attached to lipid glycolipid) 2. Epidermal Growth Factor like domain 3. Consenus repeats
37
IgSf (immunoglobulin superfamily)
Immunoglobin domain/fold Calcium independent extracellular domain adhesion molecule trans heterophillic/homphillic bidning
38
Different types of IgSf
NCAM-neural tissues/nerve cells VCAM-endothelial cells ICAM-btwn leukocytes and endothelial cells (integrins on the surface of leukocytes bind to ICAMS) more stable adhesion
39
CAMS Important in T cell interactions and binding of leukocytes to activated or resting endothelial cells
I CAM | V CAM
40
IgSf
Encoded by a single gene | alternative mRNA
41
What is the receptor for HIV-1 (tcells/helper cells)
IgSF (CD4)
42
Integrins
heterodimers (alpha and beta subunits)
43
Do Integrins have cytoplasmic or extracellular Domain?
CYTOPLASMIC DOMAIN
44
What links integrins to actin?
Connecting Protiens (Vinculin, Talin, alpha actinin)
45
What sequence do integrins recognize?
RGD sequence found in fibronectinin and laminin
46
What subunit recognizes the RGD sequence?
the beta subunit
47
What regulates the beta subunit binding in integrins?
the alpha subunit
48
What links the cytoskeleton to the ECM?
integrins
49
Laminin is found where?
in basal lamina | made by epithelial cells
50
Fibronectin is found where?
in recticular lamina | made by fibroblast
51
In hemidesmosomes integrins link...
basal lamina to intermediate filaments | **which link the basal domain to the basement membrane**
52
Steps of Homing
1. rolling: L-selectin 2. adhesion: integrin activation (trigged by inflamm substances...chemokines) 3. Transendothelial migration (diapedesis) involves f actin and myosin
53
Purpose of Homing
to help with the moment of leukocytes from the blood stream to their home ( lymph nodes and thymus) or connective tissue
54
``` Adam Proteins ( A Disintegrin A metalloprotease) ```
reversal of integrin mediated cell binding to ECM disrupted by needs zinc for proteolytic activity
55
Adam Protein Domains (3)
1. disintegrin domain (snake venom) has RGD tripeptide which binds to platelet glycoprotien gpIIb/IIA prevents platelet aggregation 2. metalloprotease domain degrades components of ECM during migration + cleavage of membrane protein at plasma level release of soluble ectodomain leads too..inflamm targets alphaTNF 3. ectodomain cleavage leads to paracrine signaling (membrane anchored growth factors)

HIstology (17 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions