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Translocation - pieces of chromosomes rearranged but no genetic material is gained or lost in the cell.

Balanced Translocation


Exchange of chromosome material is unequal resulting in extra or missing genes

Unbalanced Translocation


Only acrocentric chromosomes affected in this translocation

Robertsonian Translocation


Name acrocentric chromosomes



Robertsonian Translocation

45 chromosomes
Two acrocentric chromosomes attach - common 13+14
14+21, 15+22
carrier is healthy
baby healthy if normal chromosome 13 and 14 passed, and if only one translocated (containing 13 and 14 passed)

problem - if translocated and on standalone chromosome passed - baby have extra - trisomy of either 13(patau - miscarry or some may survive) or 14(miscarry)