Mycobacterium Tuberculosis Flashcards Preview

Meharry Micro > Mycobacterium Tuberculosis > Flashcards

Flashcards in Mycobacterium Tuberculosis Deck (24):
1

What are the 2 most imporant conditions caused by myco bacterium

Tuberculosis and leprosy

2

What percent of the world is affected by TB

1/3

3

What connection is there between TB and aids

Causative agent of disseminated infection in aids patients

4

Are mycobacterium aerobic or aerobic

Aerobic

5

Do mycobacterium stain in the gram stain procedure

They don’t stain very well, but can kinda stain gram +

6

Are mycobacterium heat sensitive

Yes

7

What stain would be used in diagnosis

Ziehl Nielsen - since you cant do gram stain

8

What are the steps to the acid fast staining

Go look it up, she will ask about this stain

9

List the virulence factors

1. Cord factor
2.sulfatides
3. LAM

10

What is the function of sulfatides

Inhibits fusion of phagosome and lysosome

11

List 2 functions of LAM

( virulence factor) Inhibits macrophage activation, scavenges oxidative radicals

12

TB is a chronic _______

Pneumonia

13

Pt has has fatigue, weight loss and coughs up sputum with blood

Tb

14

Describe the onset of TB

Insidious

15

What generates the most nuclei

Sneezing- transfers 10 feet away

16

Can tuberculosis replicate in macrophages

Yes!

17

Can tb grow in the lab

Yes

18

What cytokine inhibits mycobacterium growth

TNF - Gamma

19

The immune response causes damage to the

Lungs

20

Pts deficient in what 2 things are at higher risk

Inf-gama and TNF alpha

21

Most immunocompetant patients have infections that are restricted to the

Lungs

22

If you are infected does it mean that you have the disease

No , it just means a positive skin test

23

What stain is used to diagnose Tb

Acid fast stain is initially done

24

What media is used to grow them

Lowenstein Jensen Middle brook