Neonate, Misc + CDB Flashcards
60% of newborns are jaundiced b/c spleen removes excess RBCs carrying HbF -> hemolysis -> high blood Hb -> high bilirubin
Transient hyperbilirubinemia of the newborn
when is jaundice in the newborn considered pathologic
Any of the following:
1) if appears on 1st day of life or after 1st 2 wks or persists after 2 wks
2) total bilirubin >5 mg/dL/day or >0.5 mg/dL/hr
3) total bilirubin >15 mg/dL
4) direct bilirubin >10% of TB
5) Persists beyond 1 week in term and 2 weeks in preterm
whats the most serious complication of pathologic jaundice in the newborn
kernicterus
how to treat pathologic jaundice in the newborn
- phototherapy w/ blue-green light (12-20 mg/dL; 270 nm breaks down bilirubin to prevent kernicterus, toxic to retina)
- exchange transfusion: if bilirubin >20-25 mg/dL
Icteric sclera, bilirubin level
> 2 mg/dL
AKA retrolental fibroplasia; ↓ vascularity of retina
ROP
Absence of UGDP causing an increase in indirect bilirubin. These infants present in the first 24 hrs and die within the 1st yr of life.
Crigler Najjar
Milder form of Crigler Najjar
Gilbert
___–>↑ UGDP enzyme–>↑ conjugation of bilirubin–>↓ unconjugated bilirubin; can help ↓ neonatal jaundice
Phenobarbital
Peak B1 at 12 mg/dL at 3rd DOL or 15 mg/dL at 5th DOL for premature infants
Physiologic jaundice
Criteria for physiologic jaundice
1) after 48 hrs of life 2) TB not increasing > 5 mg/dL/day 3) DB less than 10% of TB 4) Resolves by 1 week in term and 2 weeks in preterm
Jaundice is ALWAYS pathologic if
Bilirubin >15mg/mL; at first day of life
What are the two inborn disorders of metabolism that lead to an UNCOJUGATED hyperbilirubinemia?
Gilbert’s and Crigler-Najjar
Physiologic hyperbilirubinemia is seen ___, peaks at ___, and resolves over ___
After the first 24 hours of life, 3 days, 2 weeks
What are the Danger Signs in Jaundiced Infants?
(1) Family history of significant hemolytic disease, (2) Vomiting, (3) Lethargy, (4) Poor feeding, (5) Fever, (6) Onset of jaundice after the third day, (7) High-pitched cry
MCC of jaundice?
Unconjugated hyperbilirubinemia (indirect): physiologic and breastfeeding associated
Management for breast milk jaundice
stop breast feeding for 2-3 days, using formula instead; then resume nursing
Type of bilirubin increased in breast milk jaundice
Unconjugated
Onset of breastfeeding jaundice
3-4 DOL
Onset of breastmilk jaundice
7th DOL
Increases risk of physiologic jaundice
Preterm, diabetic mother, asian
Bilirubin levels drop rapidly when breastfeeding stops
Breastmilk jaundice
Causes of pathologic jaundice
1) Extrahepatic cholestasis (biliary atresia, choledochal) 2) Intrahepatic cholestasis (neonatal hepatitis, inborn errors of metab, TPN cholestasis) 3) Dubin-Johnson 4) Rotor 5) TORCH
To reduce incidence of breastfeeding jaundice
Frequent breastfeeding (>10/24h), discourage 5% dextrose or water