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Pathology > Neoplasia > Flashcards

Neoplasia Flashcards

1
Q

Most common type of abnormality involving proto-oncogenes

A

RAS

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2
Q

EGFR

A

Lung

Proto-oncogene

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3
Q

HER2

A

Breast

Proto-oncogene

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4
Q

JAK2

A

PV, essential thrombocytosis, primary myelofibrosis

Proto-oncogene

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5
Q

ABL

A

CML

Proto-oncogene

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6
Q

BRAF

A

Hairy cell leukemia

Proto-oncogene

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7
Q

MYC

A

Burkitt lymphoma and neuroblastoma

Proto-oncogene

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8
Q

CDK4

A

Glioblastoma

Proto-oncogene

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9
Q

Governor of the cell cycle

A

Rb

Hypophosphorylated > cells cannot pass G1-S checkpoint

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10
Q

Guardian of the genome

A

p53

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11
Q

Rb

A

Retinoblastoma

Tumor suppressor gene

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12
Q

Li-Fraumeni

A

p53

Tumor suppressor gene

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13
Q

Cancers caused by EBV (3)

A

Nasopharyngeal CA, B-cell NHL, Burkitt lymphoma

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14
Q

Tumor lysis syndrome

A

Hyperkalemia, hyperphosphatemia, hyperuricemia, hypocalcemia

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Pathology (13 decks)

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