Flashcards in nephrology Deck (42):
1
acidosis and acidemia
acidosis= low serum bicarb
acidemia= serum pH<7.35
2
alkalosis and alkalemia
alkalosis= high serum bicarb
alkalemia=serum pH >7.45
3
effects of acidosis
decrease in force of cardiac contractions
decrease in vascular response to catecholamines
diminished response to the effects and actions of certain meds
4
effects of alkalosis
interferes w/ tissue oxygenation
interferes w/ normal neurological and muscular functioning
5
what causes oxy curve to shift to right
increased H ions (decrease in pH), increased CO2, increase in temp
6
mudpiles
methanol
uremia
DKA
paraldehyde
INH, IRON
Lactic acidosis
ethylene glycol
salicylates
7
used CAR (non anion gap)
ureteral sigmoid diversions
saline admin
endocrinopathies (addisons, spironlacone, hyper PTH)
diarrhea
carbonic anhydrase inhibitors
hyperalimentation
RTA
8
when are urine Anion gaps seen
urine anion gap>20 is seen in metabolic acidosis
If urine anion gap is 0 or negative but serum Anion gap is positive the source is most liley GI (diarrhea or vomitting)
9
when to use winters and summers formula
in metabolic acid base disorders...used to calculate respiratory compensation
Winters= metabolic acidosis (when projected CO2 is higher than actual there is respiratory alkalosis....when projected co2 is lower than actual there is concommittent respiratory acidosis)
summers= metabolic alkalosis (when projected CO2 is higher than actual there is respiratory alkalosis...when projected CO2 is lower than actual there is concommittent respiratory acidosis)
10
triple ripple
calculate the delta anion gap
tells if 3rd derangement
11
metabolic alkalosis
GI hydrogen loss
12
contraction alkalosis
basically is DEHYDRATION
loss of large volume of fluid and leave HCO3 in body then its more concentrated and get alkalosis
caused by: loop diuretics, thiazides, prolonged vomiting (if giving diuretic need to monitor this), sweat loses in pts w/ cystic fibrosis (cause H and Cl are secreted together)
13
what do you need to do if have metabolic derangment
check for compensation by summers or winters
14
what do you need to do if have respiratory derangement
check for compensation by looking for change in bicarb
15
what do you want to do before you get an ABG
allens test
16
causes of metabolic alkalosis
vomiting or NG suction, increase aldosterone secretion, loop/thiazide diuretic, hypercalcemia, hypokalemia, contraction alkalosis (massive diuresis, sweat losses in Cystic fibrosis), posthypercapnic alkalosis ( usually by mechanical ventilation)
17
posthypercapnic alkalosis
overcorrect someone's co2 (wrong ventilator setting)
18
2 basic categories of diseases when kidney's retain HCO3
differentiated by response to NaCl
1. chloride responsive (10) (these problems are telling kidney to retain HCO3 so NaCl won't help)
a. excess mineralocorticoid (cushings syndrome, conn's syndrome, exogenous steroid admin, bartter syndrome)
19
tx of chloride responsive
replace volume w/ NaCl if depleted
correct hypokalemia if present
20
tx of chloride resistant
treat underlying problem such as stop steroids, etc
21
can get metabolic alkalosis from blood (8 or more units)
true (due to citrate in blood)
22
waste products of metabolism
urea, creatine, uric acid
23
BUN increased w/ creatinine normal (>20/1)
prerenal azotemia
catabolic state w/ increased muscle breakdown
GI hemorrhage
High protein intake
drugs (tetracycline, steroid)
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BUN increased and creatinine increased (>20/1)
postrenal azotemia (obstructive uropathy)
prerenal azotemia superimposed on renal disease
basicaly post renal stuff
25
decreased ratio w/ decreased BUN (<10/1)
acute tubular necrosis
low protein diet/ starvation/ liver disease
repeated dialysis
SIADH
pregnancy
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decreased ratio w/ increased creatinine
rhabdomyolisis
muscular pts who get renal failure
27
purpose of urinalysis
detect systemic disturbances (endocrine abnormalities and metabolic disturbances)
detect intrinsic kidney/urinary system disorders (kidney disease/uti)
28
low specific gravity casues
diabetes insipidus
well hydrated
tubular damage and renal abnormalities
29
high specific gravity
diabestes
adrenal insuffieciency
hepatic disease
CHF
excessive water or other loss of water
30
severity of Na levels
>130= usually not treated
120-130= depends on symptoms and situations
120< panic level
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sxs of hyponatremia
fatigue and malaise are first sxs
32
hypotonic hyponatremia
due to GI loses or renal loses
can result in sxs of neuronal cell expansion and cerebral edema
Nausea, HA, seizure, coma, death
tx- normal saline slow bolus (1000cc over 1 hours)
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hypervolemic hyponatremia
cirhosis, renal failure, CHF
tx- restrict fluids 1000-1200
restrict Na1000-1200
can use loop diuretic
34
hypervolemic hypernatremia
Iatrogenic
Hyperaldosteronism
35
hypovolemic hypernatremia
renal loses (diuretics, renal disease)
extrarenal loses (sweating, diarrhea, fluid shifts (burns)
36
Euvolemic hypernatremia
diabetes inspidus
hypodipsia
37
hypervolemic hyponatremia
CHF
liver failure (cirrhosis)
nephrotic syndrome
38
hypovolemic hyponatremia
renal loss
extra renal loss
39
euvolemic hyponatremia
SIADH
hypothyroid
polydipsia
adrenal insuffieciency
40
pseudohyponatremia
increase glucose
increase lipids
increase proteins
increase urea
41
what causes hyperkalemia
renal failure
volume depletion
adrenal insuffieciency
ACE inhibitors
spironlactone
increase in K intake (oral or IV)
pseudohyperkalemia
decrease insulin
trauma
beta blockers
acidosis
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