Neuro Oncology

Question 0

Lesion localizationn: Inferior Quadrantanopia

Answer 0

Deep partietal lobe @ optic radiations

Question 1

Lesion localization: Superior quadrantonopia

Answer 1

Temporal lobe @ myers loop

Question 2

Lesion localization: Alexia without Agraphia

Answer 2

Optic radiations + Posterior Corpus Callosum

Question 3

Meningioma
Comes from:
is ______-axial:
Histology:

Answer 3

Comes form arachnoid cells, may be attached to dura.
Is extra axial -> pushes in on brain to create focal sx
histology shows concentric spindle cell WHORLS and ‘psammoma bodies’, laminated calcifications.

A slow growing, treatable tumor.

Question 4

The most common intra axial primary brain tumors are:

Answer 4

Gliomas

Question 5

‘Glioma’ includes:

Answer 5

Astrocytomas - large, hard to remove
Oligodendroglioma - slow growers
Glioblastoma multiforme -most malignant and MOST COMMON

Question 6

Glioblastoma multiforme on histology will show:

Answer 6

Necrosis due to fast growth
Pseudopalisading pleomorphic cells bordering central areas of necrosis.
This tumor can cross the corpus callosum

Question 7

Neurolemoma/schwannoma

Answer 7

Derived from the covering of nerve.
Most common form= acoustic neuroma of vestibular nerve
Resctable, slow growing

Question 8

Ependymoma
Commonly Found?
Seen in?

Answer 8

Often found in 4th ventricle -> can cause hydrocephalus. Sometime resectable but overall poor prognosis.

Seen in CHILDREN

Question 9

Primitive neuroectodermal tumors
Seen in:
Commonly found in:
Histologic apearance:

Answer 9

(Usually medulloblastomas)
Seen in children
Found in posterior fossa
Shows strong basophilic appearance (horner white rosettes)

Question 10

Pilocytic astrocytoma
Seen in:
Found in:

Answer 10

Seen in children
Often in the posterior fossa (cerebellum)
-> Can be in pons but not common.
Have good prognosis because they are well circumscribed.

Question 11

Hemangioblastoma
Often found:
Seen in:
Associated with:

Answer 11

Found in cerebellum
A rare tumor of ADULTS
Associated with Von Hippel Lindau syndrome (mutation in VHL tumor suppressor gene)

Question 12

Pituitary adenoma
Seen in:
Sequelae:

Answer 12

Seen in adults.
Can cause bitemporal hemianopia and hypo/hyper pituitary function. (diabetes insipidous, hypogonadism, hypothyroid, hypoadrenalism)

Question 13

T/F:

An LP should not be performed on a pt with an SA hemorrhage

Answer 13

False,

it is safe and helps to dx an SAH with an LP

Question 14

T/F:

It is not safe to perform an LP on a pt with elevated ICP

Answer 14

True. Do not perform LP on pts with high ICP or a known mass (risk of herniation)