Neuro/Psych 5 Flashcards Preview

ID/LC Step Review > Neuro/Psych 5 > Flashcards

Flashcards in Neuro/Psych 5 Deck (17):
1

What is incidence?

# of new cases of a disease/year divided by total pop'n at risk for disease (doesn't already have it)

2

Where does the AA bind on tRNA?

The 3' end

This corresponds to the anticodon read on the opposite side (the top of the t)

3

What is kinesin?

- Microtubule-associated ATP-powered motor protein
- Facilitates anterograde transport of NT-containing secretory vesicles down axons to synaptic terminals

4

What are telangiectasias?

Superficial blanching nests of distended capillaries

5

Ataxia telangiectasia

Includes TRIAD:
- Cerebellar ataxia
- Telangiectasias
- Increased risk of sinopulm infections

AR

ATM gene defect => role in DNA break repair

IgA deficiency, predisposed to ^ed risk of hematologic malignancies

6

Neurofibromatosis type I

aka von Recklinghausen disease

AD

- Mutation in NF1 tumor suppressor gene
- Pts develop a shit ton of cutaneous neurofibromas made of Schwann cells

7

Schwann cells embryologic derivative

Neural crest (from ectoderm)

8

Wernicke syndorme tria

- Oculomotor dysfunction
- Ataxia
- Confusion

Due to Thiamine (B1) deficiency

9

Korsakoff syndrome

complication of Wernicke encephalopathy

Memory loss => permanent even w/ Thiamine tx

10

Pathophys of Wernicke-Korsakoff syndrome

- Chronic thiamine def => impairs neuronal energy use => cell death & atrophy
- Lesions are paraventricular & often involve mamillary bodies

11

Tx of Wernicke-Korsakoff?

Thiamine IV

Admin of glucose before Thiamine => worsens symptoms

12

MOA of lamotrigine

- Blocks VG-Na channels
- Treats partial and generalized seizures and bipolar disorder

13

SEs of lamotrigine

- especially kids

14

What is Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN)?

- It's a life-threatening rash
- SE of lamotrigine, carbamazepine, phenobarbial, & phenytoin
- Epidermal necrosis & subepidermal bullae
- SJS 30% of body surface

Flu-like sx + rash that goes away w/ discontinuation of meds

15

What are types of cholinesterase inhibitors?

- Physostigmine
- Neostigmine
- Pyridostigmine

16

What are the two reasons exacerbations of myasthenia gravis in pts being treated w/ cholinesterase inhibitors may occur?

- Myasthenic crisis (not enough drugs)
- Cholinergic crisis (too much of the drug aka too much Ach)

17

How do you differentiate between myasthenic crisis and cholinergic crisis?

Tensilon test (infusion of edrophonium)

Myasthenic crisis - Tensilon responsive

Cholinergic crisis - NOT tensilon responsive