Flashcards in Neurobiology of psychosis II Deck (13):
Viral illness in which trimester could cause schizophrenia?
Risk of schizophrenia if you have a childhood CNS infection?
Risk increased by 50%
Frontal lobe and ventricle changes in schizophrenia?
Reduced frontal lobe volume
Reduced frontal lobe grey matter
Enlarged lateral ventricles
Ppl with schizophrenia show consistent reductions in which part of the brain?
Medial temporal lobe
What does a high FA mean? (functional anisotropy)
Higher numbers = healthy white matter tracts
-but higher FA correlated with psychotic symptom severity
What does a high MD mean? (mean diffusivity)
Higher numbers = less healthy white tracts
What do D1 receptors do?
What do D2,3,4 receptors do?
Inhibit adenyl cyclase
Inhibit voltage activated Ca2+ channels
Open K+ channels
A signalling protein that mediates cell-cellinteractions and plays critical roles in the growth and development of multiple organ systems
Essential for adaptive neural plasticity
Involved in neurite outgrowth and cortical development through its interaction with other proteins
Serotonin to D2 ratio in atypical antipsychotics
High 5-HT2A to D2 ratio