Neurobiology of psychosis II Flashcards Preview

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Flashcards in Neurobiology of psychosis II Deck (13):
1

Viral illness in which trimester could cause schizophrenia?

2nd trimester

2

Risk of schizophrenia if you have a childhood CNS infection?

Risk increased by 50%

3

Frontal lobe and ventricle changes in schizophrenia?

Reduced frontal lobe volume
Reduced frontal lobe grey matter
Enlarged lateral ventricles

4

Ppl with schizophrenia show consistent reductions in which part of the brain?

Temporal cortex
Medial temporal lobe

5

What does a high FA mean? (functional anisotropy)

Higher numbers = healthy white matter tracts
-but higher FA correlated with psychotic symptom severity

6

What does a high MD mean? (mean diffusivity)

Higher numbers = less healthy white tracts

7

What do D1 receptors do?

Stimulate cAMP

8

What do D2,3,4 receptors do?

Inhibit adenyl cyclase
Inhibit voltage activated Ca2+ channels
Open K+ channels

9

A signalling protein that mediates cell-cellinteractions and plays critical roles in the growth and development of multiple organ systems

Neuregulin

10

Essential for adaptive neural plasticity

Dysbindin

11

Involved in neurite outgrowth and cortical development through its interaction with other proteins

DISC-1

12

Serotonin to D2 ratio in atypical antipsychotics

High 5-HT2A to D2 ratio

13

Definition of atypical antipsychotics?

Less likely to cause atypical symptoms