Flashcards in Neurochemistry of Memory Deck (28):
This part of the brain is responsible for emotional responses
Part of the brain involved in declarartive (explicit) memory
Medial temporal lobe
Affects mood, hunger, sleep and arousal
Influences movement, learning, attention and emotional
Undersupply linked to depression
Oversupply linked to schizophrenia
Undersupply linked to tremors and decreased mobility in Parkinsons
Undersupply linked to ADHD
Neurotransmitter that enables muscle action, learning and memory
Which neurones deteriorate as Alzheimer's disease progresses?
Helps control alertness and arousal
Undersupply can depress mood and cause ADHD-like problems
Undersupply linked to seizures, tremors and insomnia
GABA (bc its inhibitory so not enough = your body is super excited)
Oversupply can stimulate the brain producing migraines or seizures
Glutamate (why some people avoid MSG foods haha)
Most frequent neurotransmitter in the CNS
Which channels does ACh work on and how?
Inhibits nicotinic ion channels by depolarisation
Key role in memory, attention and arousal
Which receptors does glutamate work on?
This is involved in post-synaptic long term potentiation
These receptors produce rapid responses to glutamate
These receptors are responsible for synaptic plasticity and are key in long term potentiation
-how do they work?
-allow Calcium influx
(glutamate responsible for this)
(AMPA also play a role)
Agonists reduce or prevent neuro inflammation and modualte mitochondrial function
Role of ApoE
Membrane stability and repair
-problems with this gene in alzheimers
Role of tau protein
Purpose of striatal interneurones
Purpose of the nucelus basalis of Meynert?
Purpose of medial septal nucleus?
Learning and memory