neurocog disorders

Question 1

major NCD have ____decline, mild NCD have____decline

Answer 1

significant; modest

Question 2

domains evaluated for NCD (6)

Answer 2

1. complex attn
2. executive fxn
3. learning/memory
4. language
5. perceptual motor
6. social cognition

Question 3

risk factors for AD (4)

Answer 3

1. advanced age
2. famhx
3. down’s syndrome
4. apolipoprotein E4

Question 4

neurofibrillay tangles, neuritic plaques, excess amyloid

Answer 4

only things that can definitively dx AD

Question 5

binswanger’s disease

Answer 5

vascular disease/multi-infarct dementia

Question 6

2nd most common type of dementia

Answer 6

multi-infarct dementia

Question 7

subclinical parkinsonism, psychosis, autonomic dysfxn, gradual progressive cognitive impairment

Answer 7

lewy body disease

Question 8

tx of lewy body disease

Answer 8

cholinesterase inhibs

Question 9

what must be avoided in tx of lewy body disease

Answer 9

antipsychotics

Question 10

impairment of the temporal and frontal lobes; occurs in 50’s, disinhibition/apathy, language problems, steadily progressive

Answer 10

pick’s disease (frontotemporal disease)

Question 11

mild repetitive concussions, followed 8-10 yrs later by neuropsych sx

Answer 11

chronic traumatic encephalopathy

Question 12

types of subcortical disease (4)

Answer 12

1. PD
2. MS
3. HD
4. vascular disease

Question 13

huntington’s is what mode of inheritance

Answer 13

autosomal dominant

Question 14

choreoathtoid movements, changes in mood/personality, flat affect, rapid & soft speech

Answer 14

HD

Question 15

triad of normal pressure hydrocephalus

Answer 15

1. confusion
2. ataxic gait
3. urinary incontinence

Question 16

how to determine if ventriculo-peritoneal shunt is beneficial for tx of normal pressure hydrocephalus

Answer 16

LP

Question 17

once traumatic brain injury is stabilized and it doesn’t improve

Answer 17

static encephalopathy

Question 18

tx of wernicke’s encephalopathy

Answer 18

thiamine

Question 19

delirium, ocular changes, gait disturbance in alcoholics

Answer 19

wernicke’s encephalopathy

Question 20

what is mahor/mild neurocognitive disorder, amnestic-confabulatory type

Answer 20

korsakoff’s syndrome

Question 21

rash, fatigue, HA, focal neuro signs, encephalitis, cognitive sx

Answer 21

lyme disease

Question 22

tx of lyme disease

Answer 22

Abx

Question 23

onset middle-old age, psych disturbances, tremor

Answer 23

cruetzfeldt-jakob

Question 24

develops over a short period and fluctuates

Answer 24

delirium

Question 25

____% hospitalized patients are affected by delirium

Answer 25

30%

Question 26

risk factors for delirium (4)

Answer 26

1. age 2. nursing home 3. pre-existing brain damage 4. male

Question 27

tx of MCI

Answer 27

encourage catastrophization

Question 28

initial labs for NCD

Answer 28

1. CBC 2. CMP 3. Vit B12 4. thyroid studies

Question 29

what genes can be assessed for early onset AD

Answer 29

Prensilin 1/2, APP

Question 30

who determines decision making capacity

Answer 30

attending physician

Question 31

sexually inappropriate patients can be tx'd with?

Answer 31

antidepressants

Question 32

antipsychotics are assc'd with ____in dementia patients

Answer 32

higher mortality rate

Question 33

carbamazepine can be used for what type of patients

Answer 33

manic, explosive

Question 34

tx of cognitive sx (2)

Answer 34

1. ACHe inhibs | 2. memantine

Question 35

MOA of memantine

Answer 35

NMDA receptor antag