Neuroleptics (decrease DA) - for Schizophrenia Flashcards
(23 cards)
1st generation (typical or atypical?)
“Typical”
Chlorpromazine
1st gen antipsychotic, antagonize D2 receptors. Low potency, also H1 antagonist (dry mouth, constipation)
Fluphenazine
1st gen antipsychotic, D2 antagonist - high potency (Schizophrenia)
Trifluoperazine
1st gen antipsychotic, D2 antagonist - high potency (Schizophrenia)
Perphenazine
1st gen antipsychotic, D2 antagonist - high potency (Schizophrenia)
Thiothixene
1st gen antipsychotic, D2 antagonist - high potency (Schizophrenia)
Haloperidol
1st gen antipsychotic, D2 antagonist - high potency (Schizophrenia)
Tetrabenazine
VMAT2 inhibitor = Domamine-depleting in synapse (for huntington’s and tardive dyskinesia. occasionally used for schizophrenia)
Dantrolene
Direct muscle relaxant (for malignant hyperthermia associated with NMS) - NMS (neuroleptic malignant syndrome is side effect of neuroleptics)
2nd generation neuroleptics (typical or atypical?)
“Atypicals”. Pines, Dones, and Rips
Pines: more sedating b/c more antihistamine activity and more metabolic syndrome inducing
Drones: more EPS
Rips: only one (Aripiprazole), less weight side effects
Clozapine
D2 (& D1 & D4) receptor antagonist, and 5-HT receptor antagonist, and NMDA antagonist. For schizophrenia when other drugs don’t work, must monitor WBC. 2nd gen neuroleptic
Olanzapine
D2 antagonist, 5-HT antagonist (lessens EPS risks). For schizophrenia. halts mania. 2nd gen neuroleptic
Quetiapine
D2 antagonist, 5-HT antagonist (lessens EPS risks). For schizophrenia. halts mania. 2nd gen neuroleptic
EPS
Extrapyramidal syndrome: when DA forced too low => Akathesia, Dystonia, Parkinsonism, NMS (neuroleptic malignant syndrome = hyperthermia, muscle rigidity, vital sign instability, and Rhabdomyolysis)
NMS
Neuroleptic Malignant Syndrome: When DA forced too low => hyperthermia, muscle rigidity, vital sign instability, and Rhabdomyolysis (also EPS)
Asenapine
D2 antagonist, 5-HT antagonist (lessens EPS risks). For schizophrenia. halts mania. 2nd gen neuroleptic
Risperidone
D2 antagonist, 5-HT antagonist (more EPS risks). For schizophrenia. halts mania. 2nd gen neuroleptic
Ziprazidone
D2 antagonist, 5-HT antagonist (more EPS risks). For schizophrenia. halts mania. 2nd gen neuroleptic
Paliperidone
D2 antagonist, 5-HT antagonist (more EPS risks). For schizophrenia. halts mania. 2nd gen neuroleptic. Active metabolite of risperidone
Iloperidone
D2 antagonist, 5-HT antagonist (more EPS risks). For schizophrenia. halts mania. 2nd gen neuroleptic
Lurasidone
D2 antagonist, 5-HT antagonist (more EPS risks). For schizophrenia. halts mania. 2nd gen neuroleptic. least weight side effects of all SGAs
Aripiprazole
Partial D2 and D3 agonist, partial 5-HT 1a agonist, 5-HT 2a antagonist. for schizophrenia, stops mania, treats depression. less weight side effects
Reserpine
Blocks VMAT => decreased release of monoamines = for hypertension and psychosis (decrease NE and DA)
