Neurotoxicity Flashcards
What has a greater affinity for hemoglobin than oxygen?
Carbon monoxide
Strychnine is what type of agent?
Neruoexcitatory agnet
Barbituates and ivermectin are what type of agent?
Neuroinhibitory agent
Nicotine is what type of agent?
Autonomic agent
What is the toxic agent in chocolant?
Methylxanthines
What are drugs commonly used to induce emesis in dogs?
Apomorphine and hydrogen peroxide
What are drugs commonly used to induce emesis in cats?
Xylazine
Toxins that produce tremors or convulsions are often treated with what drugs?
Benzodiazapines
What can you use to treat dogs with tetanus or cats with permethrin toxicity?
Methocarbamol
What is often used in dogs to decreased the absorption of a toxin?
Activated charcoal
Ivermectin toxicity can be treated with what kind of intravenous therapy?
Intravenous lipids
What is the MoA of ivermectin?
GABA agonist
Which dogs should NOT be treated with ivermectin?
MDR-1 gene mutation in collies (white feet don’t treat)
What is the MoA of methylxathines?
Phosphodiesterase inhibitors, increase cAMP
What is latrodectism?
Envenomation by black widow spiders and their genus
What toxin do black widows contain and what does it cause?
Alpha-latrotoxin causes massive release of neurotransmitters throughout the body
What is a very common clinical sign of a black widow bite?
Pain
How do you shorten recovery time of metronidazole toxicity?
Diazepam
What is the MoA of organophosphates/carbamates?
Inhibit acetylcholinesterase
How are carbamates and organophosphates different in their MoA?
Carbamates bind ACh-ase reversibly
How do you treat organophosphate/carbamate tox?
2-PAM or Pralidoxime
What is the MoA of permethrins/pyrethroids?
Delay opening/closing of voltage-gated sodium channels
What is the MoA of bromethalin?
Uncouples oxidative phosphorylation
Spasms and full body twitching in cats is caused by what toxicity?
Permethrins
