Seizures Flashcards

1
Q

How do you treat an active epilepticus episode?

A

Rectal diazepam

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2
Q

Occurs in 1-5yo animals and causes generalized tonic-clonic seizures w/o interictal abnormalities

A

Idiopathic epilepsy

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3
Q

Where do seizures originate?

A

Prosencephalon

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4
Q

What is a seizure?

A

Hyper-syncrhonous firing from a group of neurons

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5
Q

What types of focal/partial seizures are there?

A

Simple and complex

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6
Q

Abnormal electrical activity in one area that can spread to other areas

A

Jacksonian seizure

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7
Q

Tonic-clonic seizures are classified as _____ seizures

A

Generalized

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8
Q

Abson seizures are classified as _____ seizures

A

Generalized

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9
Q

With which category of seizures is consciousness lost?

A

Generalized

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10
Q

Which type of focal seizure can have some loss of consciousness?

A

Complex

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11
Q

Period of abnormal behavior leading up to a seizure

A

Pre-ictal

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12
Q

Phase of the seizure itself

A

Ictal

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13
Q

How long do most seizures last?

A

2min

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14
Q

Period of abnormal behavior after a seizure

A

Post-ictal

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15
Q

How long does a post-ictal phase usually last?

A

Less than 1h but can last a couple of days

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16
Q

What do you call two or more seizures within 24h period?

A

Cluster seizures

17
Q

Why are cluster seizures serious?

A

One seizure makes the brain more likely to have another seizure (can lead to status epilepticus)

18
Q

What is status epilepticus?

A

One seizure lasting >5min or repeated seizure w/o recovery between events

19
Q

What are metabolic (extracranial) causes for seizures?

A

Toxins, hepatic encephalopathy, hypoglycemia

20
Q

What are structural (intracranial) causes of seizures?

A

Neoplasia, infectious dz, inflammation

21
Q

How do you dx a structural cause of a seizure?

A

MRI, CSF analysis, infectious dz testing

22
Q

What is the most common cause of seizures in dogs?

A

Idiopathic epilepsy

23
Q

When do seizures usually start in dogs?

A

Between 1-5yo

24
Q

How many seizure dogs can be well controlled with medication?

25
What emergency drugs do you give to a seizure that is happening now?
Benzodiazepines, barbiturates (enhance GABA which is an inhibitory receptor)
26
What are side effects of benzos and barbiturates?
Sedation and resp depression
27
What are maintenance seizure medications?
Phenobarbitol, potassium bromide, oral benzodiazepines
28
This dug works at GABA, is metabolized in the liver, and causes PU/PD/PP and induces cytochrome p450 system (can change metabolism of other drugs)
Phenobarbitol
29
Which liver enzyme will be increased with phenobarbitol?
ALP
30
Which drug works at GABA, is excreted in the kidney, causes PU/PD/PP, and causes reactive pneumonitis in cats
Potassium bromide
31
What are issues with oral benzodiazepines?
Tolerance develops in dogs, hepatic failure in cats