Norton

Question 1

Hematuria, RBC casts in urine

Answer 1

Nephritic syndrome

Question 2

Azotemia, hypertension, mild proteinuria, edema, oliguria

Answer 2

Nephritic syndrome

Question 3

Acute proliferative glomerulonephritis (post streptococcal/post infectious), nonstreptococcal acute glomerulonephritis, and rapidly progressive crescent glomerulonephritis

Answer 3

Nephritic syndrome

Question 4

1-4wks post strep infection, children 6-10 yrs

Answer 4

Acute proliferative glomerulonephritis

Question 5

Group A beta hemolytic strep

Answer 5

Acute proliferative glomerulonephritis

Question 6

Immune complex mediated with granular immune deposits in glomeruli

Answer 6

Acute proliferative glomerulonephritis

Question 7

Increased anti-strep antibodies and decreased complement levels

Answer 7

Acute proliferative glomerulonephritis

Question 8

Light microscopy shows proliferation > Hypercellular glomeruli. Neutrophil and Monocyte infiltration

Answer 8

Acute proliferative glomerulonephritis

Question 9

EM shows humps of immune complexes subepithelially (on epithelial side of BM)

Answer 9

Acute proliferative glomerulonephritis

Question 10

Immunofluorescence shows granular deposits of IgG, IgM, and C3 along mesangium and GBM

Answer 10

Acute proliferative glomerulonephritis

Question 11

Abrupt onset oliguria, hematuria, peri-orbital edema, hypertension, mild proteinuria, RBC casts

Answer 11

Acute proliferative glomerulonephritis

Question 12

> 95% children recover with conservative trainer with Na and water balance

Answer 12

Acute proliferative glomerulonephritis

Question 13

Adults more atypical. Have sudden onset HTN, edema, and ^ BUN. Only 60% recover promptly. Over 40% get persistent proteinuria, hematuria, HTN, chronic glomerulonephritis, rapidly progressive glomerulonephritis

Answer 13

Acute proliferative glomerulonephritis

Question 14

After other bacterial, viral, or parasitic infection. Immunofluorescence shows granular deposits and EM shows subepithelia humps

Answer 14

Nonstreptococcal acute glomerulonephritis

Question 15

Inflammatory rupture of glomerular capillaries > bleeding into urinary space

Answer 15

Nephritic syndrome

Question 16

Severe glomerular injury causes rapid and progressive loss of renal function. Severe oliguria. Caused by ruptures in GBM

Answer 16

Rapidly progressive (crescent) glomerulonephritis

Question 17

Immunologically mediated with crescent formation

Answer 17

Rapidly progressive (crescent) glomerulonephritis

Question 18

Crescents (proliferation of parietal epithelial cells lining Bowman’s capsule) from ruptures in GBM allowing leakage into urinary space

Answer 18

Rapidly progressive (crescent) glomerulonephritis

Question 19

Crescents formed from proliferation of _____ epithelial cells lining Bowman’s space

Answer 19

Parietal

Question 20

Has 3 types and untreated results in death in weeks/months

Answer 20

Rapidly progressive (crescent) glomerulonephritis

Question 21

Can be renal limited or progress to goodpasture’s syndrome

Answer 21

Rapidly progressive (crescent) glomerulonephritis - type one

Question 22

Anti-GBM abs that cross rx with pulmonary alveolar BM

Answer 22

Goodpastures. Rapidly progressive (crescent) glomerulonephritis - type one

Question 23

Light microscopy > crescents.
Immunofluorescence > Ig and complement linearly along GBM.
EM > ruptures in GBM

Answer 23

Rapidly progressive (crescent) glomerulonephritis - type one