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Biochemistry II Final > Nucleotides/Nucleic Acids > Flashcards

Flashcards in Nucleotides/Nucleic Acids Deck (64)
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0

What is the energy requirement to make AMP?

GTP

1

What is the energy requirement for making GMP?

ATP

2

What is the body's preferred way of synthesizing purine nucleotides?

Salvage pathways

3

What must be available in order for salvage pathways to work?

Hypoxanthine

4

What effect does hypoxanthine have on amidophosphoribosyl transferase?

Inhibition

5

What is made when IMP is broken down?

Hypoxanthine

6

What is made when AMP is broken down?

Adenine

7

If we have the presence of hypoxanthine, what effect does that have on the committed step of the PRPP pathway?

It is inhibited & the salvage pathway is used

8

During degradation of purines to uric acid, nucleotides are converted into what?

Nucleosides

9

During the degradation of purines to uric acid, nucleosides are converted to what?

Free bases

10

During degradation of purines to uric acid, free bases are converted into what?

Common base (xanthine)

11

During degradation of purines to uric acid, what is xanthine finally converted into for excretion?

Uric acid

12

The breakdown of IMP leads to which nucleoside?

Inosine

13

The breakdown of IMP leads to which free base?

Hypoxanthine

14

The breakdown of XMP leads to which nucleoside?

Xanthosine

15

The breakdown of XMP leads to which free base?

Xanthine

16

The breakdown of GMP leads to which nucleoside?

Guanosine

17

The breakdown of GMP leads to which free base?

Guanine

18

The breakdown of AMP leads to which nucleoside?

Adenosine

19

The breakdown of AMP leads to which free base?

Hypoxanthine

20

Xanthine becomes uric acid by which enzyme?

Xanthine oxidase

21

Xanthine becomes uric acid why which type of redox reaction?

Oxidation

22

What is the final metabolic product of purine catabolism?

Uric acid

23

What is the condition caused by the accumulation of excess uric acid?

Gout

24

What is used to treat gout?

Allopurinol

25

What does allopurinol do?

Inhibits xanthine oxidase

26

Is ATP necessary for the synthesis of pyrimidine nucleotides?

Yes

27

When is the ring made during the synthesis of pyrimidine nucleotides?

FIRST

28

Where is the location for carbamoyl phosphate during the synthesis of pyrimidine nucleotides?

Cytosol

29

Where is the location of carbamoyl phosphate during the urea cycle?

Mitochondria of the liver