Pentose Phosphate Pathway Flashcards Preview

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Flashcards in Pentose Phosphate Pathway Deck (90)
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What does PPP start with?

Glucose 6 phosphate

1

What is the main enzyme in PPP?

Glucose 6 phosphate dehydrogenase

2

What is made in the PPP?

Ribose and NADPH

3

Where is the PPP located in the cell?

Cytosol

4

How many NADPH are made in the PPP from each glucose 6 phosphate?

2

5

What else is made from the irreversible reaction in PPP besides NADPH?

Ribose 5 phosphate

6

What is another named for the PPP?

Hexose monophosphate pathway

7

Is ATP produced or consumed in the PPP?

Neither! (Unique)

8

What are the two purines?

Guanine and adenine

9

What are the two pyrimidines?

Thymine and cytosine (for DNA) & uracil and cytosine (for RNA)

10

What is a nucleoside?

Nitrogenous base + sugar

11

What is a nucleotide?

Nitrogenous base + sugar + phosphate

12

What do we need ribose 5 phosphate for?

ATP, coenzyme A, NAD, FAD, nucleic acids

13

What stimulates PPP overall?

Anything that consumes ribose 5 phosphate

14

What do we use NADPH for?

Reductive biosynthesis, free radical elimination (antioxidant regeneration), detoxification, respiratory bursts

15

Is NADPH an electron donor or acceptor?

Donor

16

Is the first irreversible reaction of PPP oxidative or reductive?

Oxidative

17

What are products of the reversible, non-oxidative reactions of PPP?

Products that can be utilized in glycolysis if we need energy (G3P, fructose 6 phosphate, etc...)

18

Dehydrogenation of what substance occurs in the first step of PPP?

Glucose 6 phosphate

19

Hydrolysis of what substance occurs in the second step of PPP?

6 phosphate gluconate alpha lactone (6-phosphogluconolactone)

20

What occurs in the third step of oxidative decarboxylation in PPP?

Occurs to 6-P gluconate to yield ribulose 5 phosphate

21

What occurs in the fourth isomeric action step in PPP?

Ribulose 5 phosphate to ribose 5 phosphate

22

What are the reactants for the enzyme glucose 6 phosphate dehydrogenase?

Glucose 6 phosphate and NADP+

23

What is the product of the enzyme glucose 6 phosphate dehydrogenase?

NADPH

24

What enzyme is responsible for the oxidization of glucose 6 phosphate in the first step of PPP?

Glucose 6 phosphate dehydrogenase (main enzyme of PPP)

25

What effect does NADPH have on glucose 6 phosphate dehydrogenase?

Inhibition (because it's a product)

26

What enzyme is responsible for the hydrolysis reaction that is the second step of PPP?

Lactonase

27

What compound is used during the hydrolysis reaction in PPP using lactonase?

H20 (water)

28

What enzyme is responsible for the third step of PPP, the oxidative carboxylation?

6-phosphogluconate dehydrogenase

29

What is an extra product of the third step of PPP, besides the ribulose 5 phosphate and NADPH?

CO2 (carbon dioxide)