Odontogenesis: Tooth Dev 1

Question 1

what is histogenesis

Answer 1

differentiation of undid cells to make new tissues

Question 2

what is mineralised dental tissues

Answer 2

enamel, dentine and cementum and UNMINERALISED dental tissues - dental pulp and periodontium

Question 3

what is dental lamina

Answer 3

contributes to development of teeth

Question 4

what is vestibular lamina

Answer 4

contributes to the vestibule of mouth, form sulcus

Question 5

what is the invitation stage

Answer 5

first stage of tooth dev

Question 6

what si the bud stage

Answer 6

second stage
spherical to ovoid
epi condenses poorly

Question 7

what si the cap stage

Answer 7

3rd stage of tooth dev

tooth germ grows into cap shape

Question 8

what is the bell stage

Answer 8

4th stage

differentiation occurs to furthest extent resemble bell

Question 9

what is the crown stage

Answer 9

fully dev tooth

Question 10

what is the external enamel epi

Answer 10

outer layer of cuboidal cells that limit the enamel origin

Question 11

what si the stellate reticulum

Answer 11

of epi origin
behave like mesenchymal cells
syn collagen 1,2,3

Question 12

what is stratum intermedium

Answer 12

2 or 3 layers of cells sitting above IEE

express alkaline phosphatase

Question 13

what is inner enamel epi

Answer 13

columnar shaped cells rich in RNA

connected by desmosomes

Question 14

what is ectomesehcyme

Answer 14

neural crest cells

mesodermal somites

Question 15

what does the primary epi band give rise to

Answer 15

dental lamina

vestibular lamina

Question 16

what does the vestibular lamina do

Answer 16

grows then breaks down

froms vestibule between teeth and lips/cheeks

Question 17

tooth dev is 3 phases

Answer 17

initiation
morphogenesis
histogenesis

Question 18

what does the epi give rise to

Answer 18

ectoderm
enamel
hyaline layer of root

Question 19

what does the mesenchyme give rise to

Answer 19

ectomesenchyme

• dentine
• pulp
• cementum
• periodontium (PDL and bone)

Question 20

when is the first sign of tooth development

Answer 20

6 weeks i.u

Question 21

what happens in initiation of tooth dev

Answer 21

localised epi thickening in incisor and molar regions

Question 22

which tissues initiates tooth dev

Answer 22

epi
ecotmesenchyme or nerve
tissue remobinations

Question 23

why are a couple of important genes involved in tooth dev

Answer 23

MSX 1/2

Question 24

what does the dental lamina do in germ

Answer 24

continues to lengthen

changes shape

Question 25

what happen in tooth germ to ectomesenchyme

Answer 25

condensation

Question 26

what are the components of tooth germ

Answer 26

enamel origin dental papilla dental follicle

Question 27

what is sen at the bud stage

Answer 27

spherical/ovoid epi condensation cell prolif no morhpo/histognesis

Question 28

what is seen at the cap stage

Answer 28

cap shaped enamel organ poorly histodiff little morphogen

Question 29

what is seen at the early bell stage

Answer 29

morphs and hist diff

Question 30

what is the enamel origin in the early bells stage

Answer 30

inner enamel epi startup intermedium stellate reticulum outer enamel epi

Question 31

what does the ecotmesenhcyme do int he early bell stage

Answer 31

dental papilla - forms odontoblast and pulp | dental follicle - forms cemetnuem, PDL and bone

Question 32

what are the enamel organ component

Answer 32

inner enamel epi stratum intermedium stellate reticulum outer enamel epi

Question 33

what does the inner enamel epi contain

Answer 33

basal lamina = ADJ columnar cells at cusp tips ameloblasts = enamel

Question 34

what does stratum interediam contain

Answer 34

flattened cells

Question 35

what is the role oft he stratum intermedian

Answer 35

syn and transport to and from IEE

Question 36

what is the stellate reticulum composed of

Answer 36

star shaped cells | fluid filled extrcell space

Question 37

what s the osmotic gradient due to in the stellate reticulum

Answer 37

extracellular GAG's

Question 38

what is the role of the stellate reticulum

Answer 38

maintain shape and protection

Question 39

what is the role of the outer enamel epi

Answer 39

maintenance of shape and exchange

Question 40

what does the outer enamel epi made of

Answer 40

cuboidal cells

Question 41

what are the transitory structures

Answer 41

enamel knot enamel niche enamel septum

Question 42

what si the enamel knot important for

Answer 42

signalling centre | BMP, Shh, MSX1

Question 43

what si the enamel nice

Answer 43

2d - hole | 3d - depression

Question 44

what does the enamel septum do

Answer 44

aid change in shape from cap to bell

Question 45

what is the extracellular matrix important in

Answer 45

``` morhpgensis differentiation adhesion prolif migration polarisation ```

Question 46

what does the extracellular matrix do

Answer 46

express type 1,2,3 collagens laminin proteoglycans

Question 47

what does the extracellular matrix cause changes in

Answer 47

fibronectin tenascin typ 1,2,3 collaneg syndecan