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Developmental Biology > Tooth Development 3: Root Development > Flashcards

Tooth Development 3: Root Development Flashcards

(68 cards)

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1
Q

what is the final goal of a functioning tooth

A

fulfil role in oral cav
on outside need enamel
inside need vital parts

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2
Q

what are the major parts of tooth needed for funtionin

A 
enamel 
coronal dentine
root dentine 
cementum
pulp
alveolar bone
PDL
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3
Q

what is the crown aspect

A

enamel and dentine

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4
Q

what is the formation of enamel

A

epi to ameloblast to enamel

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5
Q

what is the formation of dentine

A

dental papilla to odontoblasts to dentine

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6
Q

what does formation of the crown require

A

reciprocal induction

epi signal required for initiation of dentine formation

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7
Q

what are the constituents of the root

A

dentine

cementum

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8
Q

what is the formation of the dentine

A

dental papilla to odontoblasts to dentine

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9
Q

what is the formation of cementum

A

dental follicle to cementoblasts to cementum

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10
Q

what are the dental papilla and dental follicle tissues

A

ectomensenchymal so need an epi initiating signal

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11
Q

what is root development driven by

A

henrtwigs epi root sheath

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12
Q

what is henrtwigs epi root sheath use in development of

A

apical dev of cervical loop region
OEE and IEE
define root morhophlogy

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13
Q

how does the HERS define root morphology

A

inductive influence on root morphogenesis and cementogenesis indirectly

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14
Q

what else done HERS do

A 
proliferates - cell div apically 
disintegrates cervically (cell rest)
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15
Q

what is dental follicle origin

A

ectomesenchyme

- mesodermal origin

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16
Q

where is dental follicle

A

between enamel organ and bone

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17
Q

what does dental follicle give rise to

A

cementoblasts
fibroblasts
osteoblasts

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18
Q

what do cementoblasts do

A

form cementum

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19
Q

what do fibroblasts do

A

form PDL collagen fibres

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20
Q

what do osteoblasts do

A

forms alveolar bone - make socket in situ around tooth

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21
Q

doe the dental follicle affect gingival tissues

A

no

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22
Q

what are the 3 layers of dental follicle

A

inner investing - vascular become cemntoblasts
loose CT
outer - lines alveolus with bone

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23
Q

what does eruption of tooth need

A

anchoring
growth of root
more dentine and pre-dentine

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24
Q

what happens as tooth erupts

A

enamel matrix proteins binds to dentine and predentine form hyaline layer of hopewell smith

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25
what GF's does HERS produce
BMP4 EGF TGF(beta)
26
what si the transcription factor used by HERS
Shh
27
what s the first stage of HERS action
induces odontoblast formation
28
what si the second stage of HERS action
pre dentine then dentine form | HERS basal lamina breaks down
29
when the hERS basal lamina breaks down what does this mean
epi cannot attach to dentine
30
what si the third stage of HERS action
HERS cells secrete enamel matrix proteins (amelogenins) on predestine surface
31
what does the action of amelogenins mean
lay down enamel mineralised ameloblast attachment is prevented hyaline layer formed
32
what is the fourth stage of HERS action
enamel matrix proteins mineralise to forth hyaline layer of hopewell smith
33
what is the fifth stage of HERS action
HERS disiitnegrates no basal lamina lack of ability to bind to hyaline layer
34
what is the sixth stage of HERS action
induction of follicle cells | - migrate to root surface and form cementoblasts
35
how is the induction of the follicle cells induced
GF's
36
how can the follicle cells attach
mesenchymal origin so don't need basal lamia to watch as interact with matrix
37
what is the seventh stage of HERS action
cementoblasts secret cementum matrix and retreat outwards
38
what is cementum
``` collagen 1 fibronectin osteocalcin osteopontin DMP1 Cementum matrix protein GF's - BMP2/4/7 ```
39
what sit he eight stage of HERS action
cementum matrix mineralises | entrapping PDL fibres
40
what does the PDL entrapment mean for he tooth
extra strength
41
what are the PDL fibres
collagen
42
what sit he ninth stage of HERS action
remnants of HERS from cell rests to malassez in PDL - cystic potential
43
what si the cel fate HERS
with age num of cell rests decrease (props apoptosis) also EMT
44
what is thought of th cell rests action
go through mesenchymal transisiton
45
in the developing area of the roots what is found
``` cementum hyaline layer dentine predentine HERS cells odontoblasts cemntoblasts rafts epi cels ```
46
what are developing cells proliferating into
dental papilla
47
where is the hyaline layer
between dentine and predentine
48
what is the hyaline layer
highlymineralised | 10uM thick sp size
49
what si the hyaline layer origin
matrix from epi cells - enamel matrix protein ectomesenchymal cells
50
what is the ole of the hyaline layer
induced cementoblasts formation | cements cementum to tooth
51
what is cementogenesis
form cementum | calcified CT cover roots
52
what are the two types of cementogenesis
acellular primary | cellular secondary
53
what are cementoblalss derived form
dental follicle
54
what do cememntoblasts do
depo matrix - precementum | collagen
55
what is acellular slow to do
increase thickness
56
what collagen type is most abundant in PDL
collagen 1
57
what si the alveolus
bone that forms around the tooth germ
58
what doe the alveolus come form
outerlayerof mesenchyme
59
when the tooth erupts what happens to the alveolus
resorption of bone to allow tooth thorugh
60
what do HERS cells cause osteogenically
differetiaion form bone cells
61
what are gubernacular canals
area between apex of deciduous and permanent tooth germ | CT though the alveolus bone
62
where is PDL
between cementum and alveolar bone
63
what does he PDL do
support the tooth
64
what doe thePDL comtain
sp CT that attach unrealised tissue covering root dentine to alv bone
65
what does PDL prod
masses of collagen fibres and hyalouronan | GF's - TGF(beta) EGF
66
whataresome collagen fibres found around the tooth
``` horizontal alveolar crest circumferential dentine-gingival trans-septal inter-radicular oblique apical ```
67
what is theintermedivte plexus
controversy | between bone and dentine collagen fibres
68
what are the number of roots controlled by
controlled by DP | sub division and prolif make extra roots under FGF's

Developmental Biology (12 decks)

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