Old Quiz Questions

Question 1

Which of the following therapeutic agents can inhibit HIV replication?

Answer 1

HAART

Question 2

HIV is thought to evolve from which of the following viruses?

Answer 2

Simian immunodeficiency virus

Question 3

Which of the following is NOT a criteria for actual AIDS?

Answer 3

Impaired or absent type III hypersensitivity reaction

Question 4

Which of the following cell can harbor HIV and pass it to CD4+ cells?

Answer 4

Dendritic cell

Question 5

Bare lymphocyte syndrome is caused by

Answer 5

Defective TAP gene

Question 6

Worldwide, the single most common cause of acquired immunodeficiency is:

Answer 6

Malnutrition

Question 7

Primary immunodeficiency diseases affecting T cells tend to be more severe than those affecting….

Answer 7

T cells regulate the adaptive immune responses

Question 8

Hyper IgM syndrome is related to deficiency of

Answer 8

CD40L

Question 9

Primary immunodeficiency diseases that affect B cells are often characterized by

Answer 9

All of the above

• Recurring bacterial infections
• Persistent viral infections
• Unresolved inflammatory responses

Question 10

Which of the following is correct?

Answer 10

All of the above
Notch is essential for B lineage
RAG mutation causes IPEX
Fas mutation causes Canale Smith
FOXP3 causes DiGeorge

Question 11

Which of the following statements is true?

Answer 11

NK cell express TCR with an invariant TCRa chain
NKT secretes IFN-y
Intraepithelial lymphocytes do not need priming
B and C

Question 12

In negative selection cells that receive _____ signal through their Ag receptors die

Answer 12

Strong

Question 13

What happens to autoreactive cells that escape the thymus

Answer 13

They can be nonresponsive in the absence of costimulation
Cannot initiate a response because self antigens are hidden
They require TCR and costimulation to be activated

Question 14

Which of the following BEST describes the relationship between natural Treg and induced Treg

Answer 14

Natural Tregs develop in thymus, induced develop in periphery

Question 15

Which effector molecule for induction of apoptosis

Answer 15

Caspase3

Question 16

Tregs have been shown to be protective against which of the following conditions

Answer 16

Inflammatory bowel disease

Question 17

Which of the following is NOT a characteristic of apoptosis

Answer 17

Release of cellular contents into extracellular space

Question 18

Which of the following best differentiates innate and adaptive immune responses

Answer 18

Innate responses are same during primary and secondary while adaptive are less robust during primary responses and stronger during secondary

Question 19

Which of the following is the BEST ex of hypersen rxn?

Answer 19

Inflammation of the airways in response to pollen

Question 20

AIDs is a

Answer 20

Secondary immunodef dz

Question 21

Conditions in which immune system attacks self-antigen are known as

Answer 21

Autoimmunity

Question 22

Which of following is the cell that gives rise to all blood cells

Answer 22

HSC

Question 23

Complement def can cause which disease

Answer 23

SLE

Question 24

Which TLRs recognize virus?

Answer 24

TLR3,7,8

Question 25

TLR4 can recognize which of the following microbial protein?

Answer 25

LPS from gram neg bacteria

Question 26

Which is true regarding neutrophil

Answer 26

All of the above - first responder during immune response - nucleus multi-lobed - granules contain variety of proteins responsible for damaging pathogen directly

Question 27

NK cells responsible for the following fxn

Answer 27

Cell mediated cytotoxicity

Question 28

Basophils are responsible for

Answer 28

Allergic response

Question 29

Which of the following transcription factor is responsible for development of all hematopoietic lineages?

Answer 29

GATA-2

Question 30

Which of the following cell is a professional antigen presenting cell?

Answer 30

Myeloid dendritic cell

Question 31

Which of the following statement is true regarding macrophage

Answer 31

Activated macrophages can present antigen

Question 32

Cytokines that act on cells nearby secreting cells are called

Answer 32

Paracrine

Question 33

Detection of large quantities of Ab light chain in serum may be an indication of

Answer 33

Multiple myeloma

Question 34

X-linked agammaglobulinemia is a genetic disorder caused by

Answer 34

Btk gene

Question 35

Which of the following is true regarding cytokines

Answer 35

Biological effect include activation, proliferation, differentiation and apoptosis

Question 36

Pleiotropic action of cytokine means

Answer 36

One cytokine produces multiple effects

Question 37

Which of the following pathogens can interfere with MHC expression?

Answer 37

Cytomegalovirus

Question 38

Which of the following is true regarding superantigens?

Answer 38

All of the above - viral or bacterial protein that binds strongly with TCR and MHC - responsible for food poisoning and toxic shock - staphylococcal enterotoxin is a superantigen

Question 39

Members of type I interferon are responsible for controlling

Answer 39

Proliferation of viral infected host cells

Question 40

Immunotherapy for RA targets which family of cytokines

Answer 40

Tumor necrosis factor family

Question 41

Which family of cytokines regulates target cell development, homeostasis or death

Answer 41

Tumor necrosis factor

Question 42

Signaling through Fas receptor causes induction of which pathway?

Answer 42

Caspase

Question 43

Innate immunity composed of

Answer 43

Physical and chemical barrier, phagocytes, granulocytes and complement

Question 44

Which of the following would be LEAST likely to express MHC class II?

Answer 44

T cells

Question 45

Inflammasomes can be activated by

Answer 45

All of the above - self-derived ATP, glucose - enviro derived silica, asbestos - pathogen like bacteria, virus, fungus

Question 46

Signaling through PRR results in

Answer 46

Secretion of antimicrobial peptide

Question 47

Genetic def of RAG1/2 results in

Answer 47

Absence of B and T cell but normal NK and myeloid cell

Question 48

Which of the following statement is true regarding MAC

Answer 48

All of the above - composed of C5b, C6-9 - enveloped viruses cannot be killed by MAC - gram + bacteria is susceptible to MAC attack

Question 49

Isotype MOST efficient at initiating a complement fixation

Answer 49

IgM

Question 50

Which of the following regulates complement.....formation of the MAC

Answer 50

Protectin (CD59)

Question 51

In VDJ recombination of lymphocyte receptor gene

Answer 51

RAG1/2 catalyze DNA breakup. Artemis opens hair pin loop, DNA ligase IV ligates the signal end

Question 52

MHC molecules

Answer 52

Are recognized by T cells

Question 53

Which of the following is an ex of cross-presentation

Answer 53

An exogenous peptide being presented on MHC class I

Question 54

Non-protein antigen like mycolic acid from mycobacterium tuberculosis can be presented by

Answer 54

CD1

Question 55

In bare lymphocyte syndrome

Answer 55

Peptides cannot be loaded on MHC molecules

Question 56

HSC cultured in the presence of which receptor ligand differentiate into T cells rather than B cells

Answer 56

Notch

Question 57

During infection whihc of the following cytokine can upregulate MHC expression

Answer 57

Interferon-a

Question 58

Double positive thymocyte can commit to which of the following cell type

Answer 58

All of the above - either CD4 or CD8 - NK T cell - Treg - IEL