Common carcinogens
Aniline dyes -> transitional cell carcinoma of bladder
Asbestos -> Mesothelioma
Nitrosamines -> Oesophageal/gastric cancer
SEs;
Cyclophosphamide
Cyclo - haemorrhagic cystitis
Adverse effects - methotrex
Myelofibrosis, liver fibrosis, lung fibrosis
Adverse effects - Bleomycin
Bleo- lung fibrosis
Adverse effects - Doxorubicin
Doxy - Cardiomyopathy`
Adverse effects - cisplatin
Nephrotoxic, ototoxic, p[eriph neuropathy
BRCA and Cancer
Increased risk of breast, Ovarian and prostate cancer
Tumour Marker - CA 125
Ovarian
Tumour Marker - Ca 19-9
Pancreatic
Tumour Marker - Ca 15-3
Breast
Tumour Marker - AFP
HCC, Teratoma
Tumour Marker - CEA
Colorectal