ophthalmology 2 Flashcards

(50 cards)

1
Q

What are the red eye red flags?

A

Severe pain, photophobia, reduced vision, proptosis, smaller pupil, raised IOP or corneal epithelium disruption

These symptoms indicate serious eye conditions that require immediate medical attention.

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2
Q

What is the middle layer of the eye called?

A

Uveal tract

This layer contains the iris, ciliary body, and choroid.

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3
Q

What does the iris contain?

A

Anterior layer of stroma with sphincter and dilator pupillae, posterior layer of pigmented epithelium

The iris regulates the amount of light entering the eye.

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4
Q

What is the function of the ciliary body?

A

Allows lens convexity and is involved in aqueous production

The ciliary body also contains muscle layers that control lens shape.

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5
Q

What is uveitis?

A

Inflammation inside part of your eye

Can be acute or chronic and may affect the anterior or posterior sections.

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6
Q

What are the investigations for uveitis?

A

ESR, FBC, ACE level, HLA typing, chest X-rays

These tests help determine the underlying cause of uveitis.

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7
Q

What complications can arise from uveitis?

A

Cataract, glaucoma, macular oedema, hypotony, band keratopathy, CME

These complications can lead to significant vision impairment.

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8
Q

What causes anterior uveitis?

A

Trauma, surgery, HZV, colitis, Crohn’s, syphilis, TB, sarcoidosis

Anterior uveitis symptoms include red eye, watering, blurred vision, and hyperaemia.

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9
Q

What symptoms are associated with posterior uveitis?

A

Floaters, blurred vision, macular oedema, disc swelling, vasculitis

These symptoms indicate inflammation affecting the back of the eye.

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10
Q

How is uveitis treated?

A

Use mydriatics, topical steroids, periocular steroid injections, intraocular steroids, systemic steroids, antimetabolites, alkylating agents

Treatment depends on the severity and underlying cause of uveitis.

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11
Q

What are mydriatics used for in uveitis treatment?

A

Relieves pain and prevents posterior synechiae

Mydriatics help to dilate the pupil and reduce inflammation.

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12
Q

What are examples of topical steroids for uveitis?

A

Dexamethasone sodium phosphate, prednisolone acetate or phosphate

These steroids help reduce inflammation in the eye.

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13
Q

What can periocular steroid injections treat?

A

Primary treatment for posterior uveitis or uveitic eyes

These injections can provide prolonged effects for inflammation control.

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14
Q

What are the complications of intraocular steroids?

A

Heightened IOP, cataract, haemorrhage, retinal detachment

These complications can occur following steroid administration in the eye.

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15
Q

What are systemic steroids used for in uveitis?

A

For uveitis unresponsive to periocular injection

Examples include oral prednisolone and IV methylprednisolone.

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16
Q

What side effects can long-term use of systemic steroids cause?

A

Cushing syndrome, osteoporosis, limitation of growth, TB, cataracts

Long-term steroid use carries significant health risks.

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17
Q

What are antimetabolites used for?

A

Bilateral uveitis that is non-infectious and reversible

They should be used after steroid therapy if there’s no response.

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18
Q

What are alkylating agents used for?

A

Retinal vasculitis

Examples include cyclophosphamide or chlorambucil.

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19
Q

What risks are associated with alkylating agents?

A

GI disturbance, bone marrow suppression, cancer, infertility, infection, allergies

These agents can have serious side effects that require monitoring.

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20
Q

What is branch retinal vein occlusion?

A

Blockage in one of the smaller veins that drain blood from the retina, potentially leading to vision loss or blurring.

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21
Q

What is central retinal vein occlusion?

A

Main vein draining blood from retina is blocked leading to fluid buildup, oxygen deprivation and so vision loss.

22
Q

What causes retinal artery occlusion?

A

Blood clot or cholesterol build up in the retina’s arteries; poor blood flow leads to pain and vision loss.

23
Q

What is retinopathy?

A

A complication of diabetic patients; can get retinal oedema, looks like thickening on biomicroscopy, abnormal vessels.

24
Q

What types of haemorrhages can occur in retinopathy?

A

Haemorrhages that look like hard exudates, shaped in clumps or rings; can also get cotton wool spots and venous irregularities.

25
What is focal diabetic maculopathy?
Diabetic macular oedema; leakages from micro aneurysms with hard exudates, leads to retinal thickening.
26
What occurs in ischaemic diabetic maculopathy?
Blood vessels in the macula become blocked or damaged, leading to vision loss and no perfusion in the capillaries in the eye.
27
What is the role of VEGF in retinal conditions?
VEGF is the main agent involved in the inflammatory process; helps endothelial cells function and neurons.
28
What is CNV and how is it identified?
CNV is sometimes identifiable as a grey-green or pinkish-yellow subretinal lesion with localized subretinal fluid and hard exudate.
29
What is ARMD?
Age related macular degeneration; progressive, chronic, blinding retinal disease leading to central vision loss.
30
What are the four types of anti-VEGF drugs?
* Alfibercept: recombinant fusion protein that binds to VEGF, longer acting * Ranibizumab: monoclonal antibody fragment developed specifically for the eye * Bevacizumab: cheaper, used ‘off label’ in the eye * Brolucizumab: smaller molecule with high binding affinity and lasts longer in eye.
31
What are the two treatment strategies for anti-VEGF injections?
* Three initial monthly injections followed by monthly review with re-injection upon deterioration of VA or on OCT * Treat and extend: initial monthly injections followed by gradual increase in between injections until deterioration is evident.
32
What complications can arise with anti-VEGF treatments?
* Lens damage * Elevated IOP * Retinal detachment or RPE tears * Ocular haemorrhage.
33
What should be done if there is persistent deterioration in visual acuity?
Permanently stop treatment if persistent deterioration in visual acuity or any changes to retina anatomically are identified.
34
What is Bevacizumab?
Full length monoclonal antibody against VEGF, approved for IV admin for metastatic colorectal cancer.
35
What is Ranibizumab?
Humanised Fab of 2nd gen, recombinant mouse monoclonal antibody directed towards VEGF, less antigenic in humans.
36
What is PDT?
Intravenous administration of a light-activated compound (e.g. verteporfin) preferentially taken up by dividing neovascular tissue activated by a low-energy laser.
37
What are combination therapies in the context of retinal treatments?
Combination therapies (e.g. PDT plus anti-VEGFs) are under investigation and may allow a reduction in the frequency of injections.
38
What are the parts of the eye?
1. Anterior segment: conjunctiva, cornea, lens, iris, ciliary body 2. Posterior segment: vitreous body, choroid, retina ## Footnote The anterior segment is responsible for focusing light, while the posterior segment is primarily involved in the eye's volume and structure.
39
What is the Vitreous Humour?
A firm gel that makes up the globe volume, made of water and collagen II ## Footnote Its functions include protecting ocular structures and maintaining intraocular pressure (IOP).
40
Where is the Vitreous Humour attached?
Attached to retina at vitreous base, macula, and optic disc margin ## Footnote This attachment is crucial for the stability and function of the retina.
41
What is the structure of the retina?
Multilaminal; contains 10 layers ## Footnote These layers are essential for the conversion of light energy into neural impulses.
42
What is the main function of photoreceptors in the retina?
Rods are monochromatic; cones help with colour vision ## Footnote Rods are more sensitive to light, while cones are responsible for color and detail.
43
What types of cells are found in the retina?
Astrocytes and bipolar cells ## Footnote Astrocytes support neuronal health, while bipolar cells transmit signals from photoreceptors to ganglion cells.
44
What is posterior vitreous detachment?
A condition that can cause complications like retinal breaks and detachment, vitreous or retinal hemorrhage, CMO, or macular hole ## Footnote This condition is often related to aging and can lead to serious vision problems.
45
What can cause syneresis in the eye?
Aging, calcium, and cholesterol issues ## Footnote Syneresis can lead to changes in the vitreous humor and affect vision.
46
What structures are examined using an ophthalmoscope?
Optic disc, macula, and fovea ## Footnote The fovea is the center of the macula and has the highest visual acuity due to being rod-free.
47
Why is the macula darker in appearance?
Due to yellow luteal pigment ## Footnote This pigment plays a role in protecting the retina from harmful light.
48
What conditions can be observed during an eye examination?
Pale disc, swollen disc, cupped disc ## Footnote These findings can indicate various ocular health issues.
49
What do cotton wool spots or macular star indicate?
Hypertensive retinopathy ## Footnote These are signs of retinal damage often related to high blood pressure.
50
True or False: The retina has 10 layers.
True ## Footnote Each layer has a specific function in the process of vision.