Oral Drug Delivery Systems Flashcards
T/F The major absorptive surface of the GIT is the small intestine.
true
Which phase of the migrating motor complex is responsible for expelling all stomach contents in the fasted state?
a. Phase I
b. Phase II
c. Phase III
d. Phase IV
e. Digestive phase
c
T/F Food decreases gastric emptying rate by increasing osmotic pressure, viscosity and volume of contents.
true
Food can increase the bioavailability of some drugs by:
a. forming complexes with drugs
b. decreasing diffusion of drugs
c. increasing dissolution of lipophilic drugs
d. competing with drugs for carrier mediated transport
c
Which of the following is part of the pre-systemic clearance mechanisms? [Select all that apply]
a. Carrier-mediated transport
b. Pg-p efflux pumps
c. CYP enzymes in the liver
d. CYP enzymes in the gut
b,d
T/F The oral route of administration is intended only for systemic drug absorption.
false
Weak acid drug in a suspension formulation will dissolve in the ________ & will have the majority of their absorption in the ____
upper part of the small intestine
ileum
T/F Dosage forms & water are considered food and will trigger the digestive phase contractions.
false
Oral dosage forms that will have to undergo dissolution prior to absorption include [Select all that apply]
a. solutions
b. emulsions
c. suspensions
d. powders
e. granules
f. tablets
g. capsules
c,d,e,f,g
Which of the following dosage forms have sizes greater than 5 mm & need the MMC Phase III to be propelled into the small intestine?
a. Solutions
b. Emulsions
c. Suspensions
d. Powders
e. Granules
f. Tablets
g. Capsules
h. Enteric coated tablets
i. Enteric coated granules
j. Extended release tables
h,j
Which of the following dosage forms may experience an increase in their oral bioavailability?
a. Suspensions
b. Enteric coated tablets
c. Reservoir tablets
d. Osmotic tablets
c
