Week 1/2

Question 1

Based on the description provided, “Inhaled Albuterol Sulfate Suspension,” answer the following questions:
The drug is?
The dosage form is?
The route of administration is?

Answer 1

albuterol sulfate
suspension
pulmonary

Question 2

Based on your understating of dosage forms, categorize the following dosage forms/ formulations as solid, liquid, or semi-solid.

1. Emulsions
2. Pastes
3. Granules

Answer 2

liquids
semisolids
solids

Question 3

Excipients which control the rate of drug release impact the drug’s

Answer 3

rate of absorption

Question 4

Which type of excipient is critical for an orally administered acid-sensitive drug?

Answer 4

Buffering agent

Question 5

How quickly to effervescent tablets dissolve compared to regular tablets?

Answer 5

faster

Question 6

Based on your understanding of dosage forms which of the excipients would you expect in a liquid dosage form? {Select all that apply}
Emulsifying agent 
Lubricant 
Vehicle 
Sweeting agent

Answer 6

Emulsifying agent
Vehicle
Sweeting agent

Question 7

Based on your understanding of dosage forms, which excipients would you expect in a semisolid dosage form? {Select all that apply}
Levigating agent 
Lubricants 
Vehicle 
Ointment base

Answer 7

Levigating agent

Ointment base

Question 8

Based on your understanding of dosage forms, which excipients would you expect in a solid dosage form? {Select all that apply}
Glidant 
Lubricants 
Vehicle 
Film coating

Answer 8

Glidant
Lubricants
Film coating

Question 9

T/F Excipients listed in the Inactive Ingredients Database can be incorporated into all dosage forms without any additional considerations

Answer 9

False

Question 10

T/F Excipients that can increase the rate of absorption aid with the disintegration of solid dosage forms.

Answer 10

True

Question 11

The major pathway of absorption for small hydrophilic molecules (MW <300 Da) is?

Answer 11

passive paracellular diffusion.

Question 12

The major pathway of absorption for small lipophilic drugs (<1000 Da) is

Answer 12

passive transcellular diffusion.

Question 13

The major pathway for most drug absorption is passive ______ transport.

Answer 13

transcellular

Question 14

T/F Drugs which are slightly hydrophobic will have higher drug absorption than very hydrophilic or very hydrophobic drugs

Answer 14

True

Question 15

As the molecular weight of a molecule increases its diffusion coefficient, _____

Answer 15

decreases

Question 16

As the radius of a molecule decreases its diffusion coefficient, _____

Answer 16

increases

Question 17

As the viscosity of a medium increases, the diffusion coefficient of a molecule in that medium, _____

Answer 17

decreases

Question 18

As the temperature increases the, diffusion coefficient of a molecule, ______

Answer 18

increases

Question 19

As the molecular weight increases the, molecular size, _____

Answer 19

increases

Question 20

If a drug has a high partition coefficient, it is lipophobic or liphophilic?

Answer 20

Lipophilic

Question 21

For an API absorption, the ideal range for log Ko/w or log Po/w is between?

Answer 21

1 to 3

Question 22

A drug has a partition coefficient of 0.333. Its log partition coefficient value is?

Answer 22

-0.478 (figure out how to calculate)

Question 23

A log Ko/w or log Po/w value of 2 indicates that the drug molecule is?

Answer 23

lipophilic

Question 24

A log Ko/w or log Po/w value of -3 indicates that the drug molecule is?

Answer 24

hydrophilic

Question 25

A log Ko/w or log Po/w value of 0 indicates that the drug molecule is?

Answer 25

equally lipohilic and hydrophilic

Question 26

A drug has log Po/w value of 2.699 indicating that; (select that all apply) the solubility ratio of the drug in oli/water is ≈ 500. the solubility ratio of the drug in oil/water is ≈ 0.431. the drug is lipophilic. the drug is hydrophilic.

Answer 26

the solubility ratio of the drug in oli/water is ≈ 500. | the drug is lipophilic.

Question 27

What happens to the permeability of a molecule if the MW of the compound increases?

Answer 27

Permeability decreases

Question 28

What happens to the permeability of a molecule if the partition coefficient increases?

Answer 28

Permeability increases

Question 29

What happens to the flux of a molecule across biological membrane if its permeability decreases?

Answer 29

Flux decreases

Question 30

What happens to the flux of a molecule across the biological membrane if the molecule concentrations C0 and Ci are equal?

Answer 30

Flux stops

Question 31

define Molecular dispersion

Answer 31

homogenous, dispersant size less than 1nm

Question 32

define Colloidal dispersion

Answer 32

non-homogwnous, dispersant size 1nm to 1um

Question 33

define Coarse dispersion

Answer 33

non-homogwnous, dispersant size greater than 1um

Question 34

Components of a solution include a ____ completely ____ in a _____ key: solvent, solute, dissolved

Answer 34

solute, dissolved, solvent

Question 35

Increasing the dissolution rate: - increases solubility - decreases solubility - dose not affect solubility

Answer 35

dose not affect solubility

Question 36

A compound that is sparingly soluble has an approximate solubility of: - 33 – 100 mg/mL - 10 – 33 mg/mL - 1 – 10 mg/mL

Answer 36

10 – 33 mg/mL

Question 37

Ionized forms of the drug have ____ aqueous solubility compared to the unionized form of the drug molecule.

Answer 37

higher

Question 38

Salt forms of the drug have ____ aqueous solubility compared to the weak electrolyte form of the drug molecule.

Answer 38

higher

Question 39

Different salt forms of the drug have _____ aqueous solubility compared to the weak electrolyte form of the drug molecules.

Answer 39

different

Question 40

Neutral molecules need co-solvents, surfactants, or non-aqueous formulations due to their ____ aqueous solubility

Answer 40

lower

Question 41

The crystalline form of the drug will have ____ solubility compared to the amorphous form of the drug.

Answer 41

lower

Question 42

Typically, solubility of solid solutes in liquid solvents _____ with increasing temperature.

Answer 42

increases

Question 43

Aqueous water-based solutions can be administered by __ routes of administration.

Answer 43

all

Question 44

Aqueous syrups contain: - 100% water and up to 100% sugar - 100% water and up to 85% sugar - 100% alcohol and up to 85% sugar - 100% alcohol and up to 100% sugar

Answer 44

100% water and up to 85% sugar

Question 45

Elixirs contain: - 60-95% water & 5 - 40% alcohol - 60-95% alcohol & 5 - 40% water - 60-95% oil & 5 - 40% alcohol - 60-95% alcohol & 5 - 40% oil

Answer 45

60-95% water & 5 - 40% alcohol

Question 46

Elixirs can be administered by ________ route(s) of administration.

Answer 46

oral & topical

Question 47

Oil solutions contain ___ oil.

Answer 47

100%

Question 48

Oil solutions can be administered by what route(s) of administration?

Answer 48

IM, topical & ophthalmic

Question 49

Which of the following vehicles can be used by all routes of administration? - Collodion - Water - Tincture - Syrup

Answer 49

water

Question 50

Drug X is available in two forms with the following aqueous solubilities: slightly soluble WA or a soluble Na salt of the WA. Which form of the drug is most appropriate for an aqueous solution dosage form?

Answer 50

Na salt of WA

Question 51

Drug X is available in two forms with the following aqueous solubilities: slightly soluble WA or a soluble Na salt of the WA. Which form of the drug is most appropriate for an oil based solution dosage form?

Answer 51

WA

Question 52

``` Drug X is very slightly soluble with a log Ko/w 2.2 and a MW of 420 Da. No salt forms of Drug X are available. Based on its solubility each dose will require 8 tablespoons. What option(s) should you consider if Drug X needs to be formulated as an aqueous solution? [Select all that apply.] Use a co-solvent Use a surfactant Use a complexing agent Use an oil vehicle ```

Answer 52

Use a surfactant | Use a complexing agent

Question 53

Which of the following excipients will you expect in a topical solution? [Select all that apply.] - Vehicle - Surfactants/complexing agents/ co-solvents - Preservatives - Sweeteners

Answer 53

Vehicle Surfactants/complexing agents/ co-solvents Preservatives

Question 54

The chemical stability of drugs in solution dosage forms can be improved by making? - aqueous solutions - powders for reconstitution - hydro-alcoholic solutions

Answer 54

powders for reconstitution

Question 55

Drug S is available as an aqueous solution. Drug S has a MW of 420 Da and a log Ko/w of -3.5. What will be the rate limiting step for Drug S in this dosage form? - Diffusion coefficient - Partition coefficient - Both diffusion coefficient & partition coefficient - Neither diffusion coefficient & partition coefficient

Answer 55

Partition coefficient