Topical DDS Flashcards
Which layer of the skin is the biggest barrier to drug delivery?
a. Stratum lucidum
b. Stratum granulosum
c. Dermis
d. Stratum corneum
e. Stratum basale
f. Stratum spinosum
d
Which of these factors increase flux across the skin?
a. Large MW drug
b. Lower surface area of application
c. Applying to dry skin
d. High concentration of drug
d
What will happen if the patient applies a topical formulation to broken skin?a. Lower drug concentration due to lower permeability
b. No effect on drug concentration as SC will not be breached
c. Higher drug concentration due to greater permeability
c
A patient comes in for a prescription for a topical formulation for her arm skin. You notice her arm is very flaky and dry. What may be a potential issue with drug absorption?
a. Drug absorption will be lower due to lower skin permeability
b. Drug absorption will be unaffected as hydration status changes don’t matter
c. Drug absorption will be higher due to higher skin permeability
a
T/F The skin as a route of administration lends itself to local action or systemic absorption.
true
What type of drug delivery system would you want to use for local drug delivery only? [Select all that apply]
a. transdermal patch
b. topical patch
c. topical ointment
d. transdermal ointment
b,c
The goal of topical drug delivery is to treat which region(s)? [Select all that apply]
a. Sebaceous glands
b. Stratum corneum
c. Liver
d. Viable epidermis
e. Dermis
f. Hair follicles
a,b,d,f
Which of the following strategies will increase drug flux from a hydrocarbon ointment base across the stratum corneum? [Select all that apply]
a. Drug concentration
b. Occlusion
c. Area of application
d. Thickness of application
b
T/F Patches are intended for transdermal use only.
false
transport across the skin is governed by what law?
Fick’s law of diffusion
what physiological factors affect the skin? [Select all that apply]
a. age
b. hydrophilicity
c. permeability
d. hydration
e. sweat
f. broken/irriated skin
g. temperature
a,c,d,f,g
T/F high lipid solubility is needed for flux across the stratum corneum
true
