Week 5/6

Question 1

Micromeritics is defined as the science of

Answer 1

small particles

Question 2

Particle size can affect\_\_\_\_\_\_\_\_. [Select all that apply]
appearance 
texture 
dissolution rate 
bioavailability 
diffusion 
partition

Answer 2

appearance
texture
dissolution rate
bioavailability

Question 3

By decreasing the particle size, what type of stability can be enhanced in a suspension dosage form?
physical stability
chemical stability
microbiological stability

Answer 3

physical stability

Question 4

Particle shape can affect\_\_\_\_\_\_\_\_. [Select all that apply]
flow 
packing 
texture 
bioavailability 
diffusion 
dissolution

Answer 4

flow
packing
texture

Question 5

A powder with an angle of repose below 35oC can be characterized as?

Answer 5

freely flowing

Question 6

Which physical property of the particle will most affect the rate of drug absorption?
particle size
particle shape
particle angle of repose particle porosity
particle density

Answer 6

particle size

Question 7

A powder dosage form is defined as a/an?
drug powder or API 
drug powder mixed with excipients 
powder for reconstitution 
agglomeration of powders

Answer 7

drug powder mixed with excipients

Question 8

A granule dosage form is defined as?
drug powder or API 
drug powder mixed with excipients 
powder for reconstitution 
agglomeration of powders

Answer 8

agglomeration of powders

Question 9

Powders for reconstitution are made to?
increase in the shelf-life of the drug 
increase the portability of the drug 
decrease the weight of the drug product 
reduce the doses needed of the drug

Answer 9

increase in the shelf-life of the drug

Question 10

T/F Dusting powders are used for systemic application

Answer 10

false

Question 11

T/F Dusting powders must be light and fluffy to ensure their efficacy.

Answer 11

false

Question 12

Drugs that typically undergo _______ are prepared by dry granulation

Answer 12

hydrolysis reactions

Question 13

Hygroscopic drugs absorb ______ when they come into contact with water and therefore should be ______ in powder & granule dosage forms

Answer 13

moisture; avoided

Question 14

Forming different crystal forms of the drug is a sign of _______ instability in powder & granule dosage forms.

Answer 14

physical

Question 15

T/F Powder & granule dosage forms are an excellent option in extending the shelf-life of chemically unstable drugs.

Answer 15

true

Question 16

Dry powder inhalers are powder dosage forms intended for the ______ route of administration

Answer 16

pulmonary

Question 17

Drug X has a MW of 330 Da and a log Ko/w of 1.4.  It is available as a powder for a solution that the pharmacist reconstitutes before dispensing and granules for suspension.  What is the rate-limiting step for Drug X in the POWDER for the SOLUTION?
Diffusion coefficient 
Partition coefficient 
Dissolution rate 
Permeability constant

Answer 17

Partition coefficient

Question 18

Drug X has a MW of 330 Da and a log Ko/w of 1.4.  It is available as a powder for a solution that the pharmacist reconstitutes before dispensing and granules for suspension. What is the rate-limiting step for Drug X in the GRANULE for SUSPENSION?
Diffusion coefficient 
Partition coefficient 
Dissolution rate 
Permeability constant

Answer 18

Dissolution rate

Question 19

A tablet is defined as a solid dosage form [select all that apply]

• with drug and excipients prepared by compression
• with drug and excipients prepared by molding
• with drug and excipients prepared by homegenization
• with drug and excipients prepared by blending

Answer 19

with drug and excipients prepared by compression

with drug and excipients prepared by molding

Question 20

Match the process with its definition:
Disintegration
Deaggregation
Dissolution
Diffusion
options:
-coarse particles break up into fine particles
-desegregation of constituent particles
-solute molecules move down the concentration gradient
-a solute entering a solution

Answer 20

Disintegration: desegregation of constituent particles
Deaggregation: coarse particles break up into fine particles
Dissolution: a solute entering a solution
Diffusion: solute molecules move down the concentration gradient

Question 21

Rank the different types of tablets in terms of their dissolution rate from fastest to slowest: MR, RDT, and IR

Answer 21

RDT>IR>MR

Question 22

Which of the following types of tablets are the cheapest to manufacture?
RDT
IR
MR

Answer 22

IR

Question 23

Which of the following tablets would be best suited for chronic use?
RDT
IR
MR

Answer 23

MR

Question 24

T/F All tablets undergo compression.

Answer 24

false

Question 25

``` Which type of tablet is suitable for incompatible drugs? Sugar-coated Effervescent Compressed Multi-compressed ```

Answer 25

Multi-compressed

Question 26

How can tablets be classified based on their release rate? RDT, IR, MR Sugar-coated, gelatin-coated, film-coated Buccal, sublingual, vaginal Compressed, chewable, effervescent

Answer 26

RDT, IR, MR

Question 27

Which type of coating may be used to modify the drug dissolution rate? [Select all that apply] Gelatin coating Film coating Sugarcoating

Answer 27

Film coating

Question 28

``` Which type of tablet undergoes mechanical disintegration before absorption? Chewable Effervescent Vaginal Buccal ```

Answer 28

Chewable

Question 29

``` Which type of tablet(s) undergo(es) slow dissolution? [Select all that apply: Buccal Sublingual Vaginal Effervescent ```

Answer 29

Buccal and vaginal

Question 30

What drug property is needed for incorporating the drug in tablet dosage form? Compressible Potent Protein-based

Answer 30

Compressible

Question 31

Drug T has two formulations – A & B. Based on your understanding of the formulation, which formulation will dissolve faster? Formulation A – Drug T with disintegrants, hydrophilic fillers, lubricants, glidants, and surfactants Formulation B – Drug T with disintegrants, hydrophobic fillers, lubricants, and glidants - Formulation A - Formulation B - Either formulation will have the same dissolution rate

Answer 31

Formulation A

Question 32

The major physical stability issues with tablet is?

Answer 32

aging

Question 33

T/F Buccal and sublingual tablets should be swallowed

Answer 33

false

Question 34

``` Drug T is available as a chewable tablet and a Buccal tablet. Drug T has a MW of 638 Da, a log Ko/w of 2.1, and a pKa of 4.9. What will be the rate-limiting step for Drug T in the CHEWABLE tablet? Diffusion coefficient Partition coefficient Dissolution rate Permeability constant ```

Answer 34

Dissolution rate

Question 35

``` Drug T is available as a chewable tablet and a Buccal tablet. Drug T has a MW of 638 Da, a log Ko/w of 2.1, and a pKa of 4.9. What will be the rate-limiting step for Drug T in the BUCCAL tablet? Diffusion coefficient Partition coefficient Dissolution rate Permeability constant ```

Answer 35

Dissolution rate