Week 4 Flashcards
A suspension is defined as a [Select all that apply]
solid dispersed in an immiscible liquid
liquid dispersed in an immiscible liquid
solid dispersed in a gas or volatile propellant
liquid dispersed in a gas or volatile propellant
solid dispersed in an immiscible liquid
solid dispersed in a gas or volatile propellant
Suspensions can be characterized based on______________. [Select all that apply]
their dispersion medium
the size of the dispersed particles
the viscosity of the external phase
the route of administration
the electrokinetic nature of the dispersed particles
their dispersion medium
the size of the dispersed particles
the route of administration
the electrokinetic nature of the dispersed particles
The zeta potential is optimized in a ______ suspension
flocculated
Colloidal suspensions have dispersed phase sizes that are?
less than 1 um
The dominant force in flocculated suspensions is _____ due to the _____ size of the flocs
gravity; larger
T/F Ready to use suspensions have drugs with low chemical stability.
false
T/F Suspensions can mask the bitter taste of drugs better than solutions.
true
A lipophilic drug delivered in a suspension requires ________ external phase of the formulation
aqueous-based
Which excipient in a suspension dosage form will promote the formation of flocs? Preservative Wetting agent Particulate hydrocolloid Thickening agent
Particulate hydrocolloid
The purpose of a wetting agent in a suspension is to?
reduce interfacial tension
Which type of electrokinetic suspension will form a loose fluffy sediment that will re-disperse easily? [Select all that apply]
Deflocculated suspension
Flocculated suspension
Flocculated suspension in a structured vehicle
Deflocculated suspension in a structured vehicle
Flocculated suspension
Flocculated suspension in a structured vehicle
The incorporation of a structured vehicle in a suspension enhances its stability by?
reducing the rate of settling
Irreversible physical stability issues with suspensions include\_\_\_\_\_\_\_\_\_\_\_. [Select all that apply] flocculation caking crystallization coalescence
caking and crystallization
T/F Suspensions are prone to chemical instabilities and cannot be used with chemically unstable drugs
false
T/F Coarse suspensions can be administered parenterally by the IV route
false
Drug S is available as an aqueous suspension. Drug S has a MW of 512 Da and a log Ko/w of 1. What will be the rate-limiting step for Drug S in this dosage form? Diffusion coefficient Partition coefficient Dissolution rate Permeability constant
Dissolution rate
A semisolid is defined as a:
solid dispersed in an immiscible liquid.
liquid dispersed in an immiscible liquid.
solid dissolved in a miscible liquid.
neither a solid nor a liquid dosage form.
neither a solid nor a liquid dosage form.
Semisolid inserts for rectal, vaginal or urethal drug delivery are called?
suppositories
Ointment bases include\_\_\_\_\_\_\_\_\_\_\_\_\_. [Select all that apply] hydrocarbon water-removable gels pastes
hydrocarbon
water-removable
Semisolid bases that can be used to incorporate drugs that hydrolyze are \_\_\_\_\_\_. [Select all that apply] gels water-soluble absorption water-removable hydrocarbon
absorption
hydrocarbon
Which of the following bases can pull water and irritate the mucosa.? Hydrocarbon Water-soluble Gel Pastes
Water-soluble
Semisolid base(s) that are occlusive include. [Select all that apply] hydrocarbon anhydrous water-removable water-soluble gel
hydrocarbon
anhydrous
Which semisolid dosage forms can only be used for the oral cavity? lozenges creams lotions ointments
lozenges
T/F Ideal drug candidates for semisolid preparation are large, hydrophilic molecules.
false
