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Flashcards in Oral manifestations of systemic diseases Deck (16)
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What is wegners granulomatosis

autoimmune disorder of unknown etiology resulting in systemic vasculitis and necrotizinf granulomatous lesions of the respiratory tract


What is the most characteristic oral manifestation of wegeners granulomatosis

Strawberry gingivitis florid granular hyperplasia (bumpy hemorrhagic and friable) reported boine destruction and tooth mobility


What are you looking for in indirect immunoflourescence for Wegener

c-ANCA clasic anti neutrophil cytoplastic antibodies diffuse cytoplasmic staining pattern


IN Wegner what are you looking for with ELISA (Enzyme linked immunosorbent assay

ID antibodies against proteinase 3 confirms positive indirect immunoflourescence


What are the halmarks of hyperparathyroidism

Stones bones groans moans brown tumor


In hyperparathyroidism what does Stones mean

Kidney stones metastatic calcification within other soft tissue: blood vessel walls sclera, dura, subcutaneous


In hyperparathyroidism what does bones mean

subperiosteal resorption of phalanges loss of lamina dura around tooth roos alterations of bony trabecular pattern (ground glass)


What is a brown tumor

Name derived from gross apearance due to hemorrhage and hemosiderin well delineated, uni or multilocular radiolucencies mandible clavicles pelvis ribs histology is identical to central giant cell lesion


What is osteitis fibrosa cystica

central fibrosis/degredation of brown tumors


What is renal osteodystrophy

end stage renal disease with striking jaw enlargement ground glass appearance can cause secondary hyperparathyroidism


Whats the def of amyloidosis

a heterogenous group of conditions characterized by the deposition of an extracellular proteinaceous substance (amyloid)


How is amyloidosis classified

organ limited systemic


what is an amyloid nodule

solitary asymptomatic submucosal deposit composed of aggregates of immunoglobulin light chains focal collections of monoclonal plasma cells may be responsible not associated with systemic alteration this type is RARE in oral soft tissues


amyloidosis and multiple myeloma

shared in 15-20% of cases


Symptoms of systemic amyloidosis

inisital non specific skin lesions then smooth surfaced firm waxy papules/plaques on eyelid retroauricular region, neck, lips Macroglossia difuse or nodular enlargement of tongue (may be ulcerated) Xerostomia and xerophtalmia if amyloid deposits in the lacrimal and salivary glands


What organ system is associated with systemic amyloidosis

end stage renal disease/dialysis