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Flashcards in Oral Path Midterm COPY Deck (184)
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1

Define Hamartoma...

Disorganized overgrowth of normal tissue in its normal location

2

Define Choristoma...

Growth of normal tissue in an abnormal location

3

Define Neoplasm...

Growth of abnormal tissue, may be either benign or malignant

4

What are some characteristics of a Benign lesion?

-Bilateral
-Rapid onset (ulceration, soft tissue swelling)
-Pain
-Growth around native structures
- Slow expansion (osseous)
- Smooth root resorption

5

What are some characteristics of malignant lesion?

- Unilateral
- Chronic, persistent (ulceration)
- Absence of pain/presence of paresthesia
- Invasion/destruction of native structures
- Cortex destruction
- Spiking root resorption

6

Define Adenoma...

Usually a benign neoplasm: Pleomorphic adenoma, oncocytoma

7

Define Carcinoma...

- Malignant neoplasm derived from epithelial cells
- Surface (skin, mucosal): Basal cell carcinoma
- Glandular: Adenocarcinoma

8

Define Sarcoma...

Malignant neoplasm derived from cells of mesodermal origin: Liposarcoma, fibrosarcoma

9

Define Metastasis...

- Spread of disease from one part of the body to another
- Tumor implants are discontinuous with the primary tumor

10

What are the 4 differentials for the gum bump differential?

1. Fibroma
2. Pyogenic Granuloma (Lobular Capillary Hemangioma)
3. Peripheral Ossifying Fibroma
4. Peripheral Giant Cell Granuloma

POF AND PGCG OCCUR ONLY ON THE GINGIVA!

11

What are the 4 Human Papilloma Virus Differential?

1. Squamous Papilloma
2. Verruca Vulgaris
3. Condyloma Acuminata (High risk types 16 & 18)
4. Heck's Disease (Multifocal Epithlial Hyperplasia)

12

What is the differential list for Multilocular Radiolucent Lesions?

MACHO!

M: Myxoma
A: Ameloblastoma
C: Central Giant Cell Lesion
H: Hemangioma (Vascular Malformation)
O: Odontogenic Keratocyst
Also may be included:
- Dentigerous Cyst
- Glandular Odontogenic Cyst

13

What is the differential for Mixed Radiolucent/Radiopaque Differential Diagnosis?

- Adenomatoid Odontogenic Tumor
- Calcifying Odontogenic Cyst
- Ameloblastic Fibro-Odontoma
- Calcifying Epithelial Odontogenic Tumor
- Ossifying Fibroma
- Fibrous Dysplasia
- Desmoplastic Ameloblastoma

14

Define Odontogenic Cyst...

Cysts lined by odontogenic epithlium

15

Which odontogenic cysts are inflammatory? Can you name 3?

1. Periapical (radicular) cyst
2. Residual periapical (radicular) cyst
3. Buccal bifurcation cyst

16

What are the 4 tumors of Odontogenic Epithelium?

1. Ameloblastoma
2. Adenomatoid Odontogenic Tumor
3. Calcifying Epithelial Odontogenic Tumor
4. Squamous Odontogenic Tumor

17

What are some Mesenchymal Odontogenic Tumors? Can you name 3?

1. Odontogenic Myxoma
2. Central Odontogenic Fibroma
3. Cementoblastoma

18

What are some mixed epithelial/mesenchymal odontogenic tumors?

1. Ameloblastic Fibroma
2. Fibroodontoma
3. Odontoma (considered a hamartoma)

19

Define Leukoplakia...

White patch that cannot be wiped off, clinical descriptions, not a diagnosis

20

Define Erythroplakia...

- Red patch or plaque-like lesion that cannot be clinically or pathologically diagnosed as any other condition
- Often represents malignant change: Up to 90% of erythroplakic lesions represent severe epithelial dysplasia, carcinoma in situ, or SCCa

21

Define Erythroleukoplakia...

- AKA speckled leukoplakia
- Frequently dysplasia or carcinoma in situ on biopsy

22

Sharply demarcated leukoplakia is concerning for...

Dysplasia!

23

What percentage of erythropakic lesions represent severe epithelial dysplasia, carcinoma in situ, or squamous cell carcinoma?

90%!

24

What is the evolution of Proliferative Verrucous Leukoplakia look like?

- Characterized by multiple, persistent, keratotic plaques that over time progress to SCC
- Verrucous hyperplasia leads to...
- Verrucous Carcinoma that leads to...
- Invasive squamous cell carcinoma
- Lesions rarely regress dispite therapy

25

Define Dysplasia...

- Abnormal tissue development
- Rapid cell turn over
- Immature epithelial cells, lack of maturation
- Can be mild, moderate, or severe (thirds of epithelium)

26

What is Squamous Cell Carcinoma in situ...

- Dysplastic change involving the full-thickness of epithelium
- Latin (in site)
- Not extending beyond the focus or level of origin
- No invasion by definition

27

Oral Squamous Cell Carcinoma is most commonly found in these 2 locations...

1. Tongue: posterior lateral most common
2. Floor of mouth (midline near frenum) Most likely location intraorally (versus oropharynx) to demonstrate early metastasis to cervical lymph nodes. Leukoplakia in this area also has a higher chance of containing dysplasia/carcinoma

28

What is the vitality of teeth associated with buccal bifurcation cysts?

Vital

29

What is the tx for buccal bifurcation cyst

curettage, do not ext

30

What is the most common dev odontogenic cyst

dentigerous