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Flashcards in Organic Disorders Deck (22):
1

Disorders association with Tourette's Disorder

ADHD (50%) and OCD (40%)

2

Genetic associations with Alzheimer type neurocognitive disorder

- mutation chromosome 1 and 4
- chromosome 19 (apolipoprotein E)
- chromosome 21 (linked to Down Syndrome)

3

What is the neurotransmitter involved in Alzheimer, how is it? why is it? Treatment options

- Ach ⬇️, because choline acetyl transferase⬇️
- "Don't memorize, listen the galactic river information":
Donezepil, memantine, rivastigmine, galantamine

4

What do you LOSS in neurocognitive disorder?

Cognitive abilities
Social functioning
Memory
Personality (change)

5

What defines Tourette's Syndrome? What is the Neurochemical changes and then treatment options?

Multiple Motor and/or Vocal tics
- Simple: rapid, repetitive contractions
- Complex: more ritualistic than purposeful
⬆️ Dopamine (Norepinephrine too) = Tx: Haloperidol, pimozide, Clonidine, Risperidone

6

Main symptom of frontal/temporal disease (Pick's disease)

- Prominent frontal lobe symptoms
Personality change
Impulsivity (desinhibited)

7

Sequence neurological manifestations of Huntington chorea

Choreoathetoid movements ▶️ neurocognitive disorder (dementia) ▶️ Psychosis

8

Main predisposing factor to vascular neurocognitive disorder to treat

Hypertension

9

How does the HIV produce the HIV-related neurocognitive disorder?

Chronic myelitis and encephalitis

10

Signs of HIV-related neurocognitive disorder, what is the earlier?

- Behavioral: dysphoric mood, apathy, social withdrawal, organic psychosis
- Cognitive: forgetfulness, 🔽 concentration, confusion
- Motor: 🔽 balance, leg weakness, poor handwriting

11

Where is the lesion if you can not recall or learn proper names?

Rostal (front) left temporal lobe

12

What aphasia allows to repeat statements? (Only one)

Transcortical

13

What is Gerstman Syndrome?

Lesion of dominant parietal cortex lobe:
- Agraphia
- Acalculia
- Finger agnosia
- Right-left disorientation
- Learning disabilities

14

What is Anton Syndrome?

Bilateral occlusion of posterior cerebral arteries:
- Cortical blindness
- Denial of blindness

15

1. What happen if destruction of ventromedial hypothalamus? 2. And destruction of lateral hypothalamus?

1. Hyperphagia and obesity
2. Anorexia and starvation

16

What is Klüver-Bucy syndrome?

Removing the amygdala

17

What structure results in damage in korsakoff syndrome?

Neuronal damage in thalamus.
Once damaged, not treatable with thiamin

18

What is Fahr Disease?

"It's a 30 CORRN in 50 houses"
Calfication
Onset at 30
Rare hereditary disorder
Resembles negatives symptoms of schizophrenia
Neurocognitive disorder at 50

19

Role of the substance P in pain

Transmit pain sensation from the skin to spinal cord.
Target of opiates.

20

Which is the most affected pathway in the brain by antipsychotics and movements disorders?

Nigrostriated pathway - major dopamine pathway
Extrapyramidal symptoms: tremors, rigid, bradykinesia, etc.

21

How do you treat extra pyramidal symptoms as side effect of antipsychotics?

- Benztropine, trihexyphenidyl, diphenhydramine: anticolinergic agents.

22

Why does the Tardive dyskinesia present?

Super sensitivity of post synaptic dopamine receptor