Osteoporosis

Question 1

Calcium Carbonate vs Calcium Citrate

Answer 1

Carbonate = 40% elemental

• Take WITH food
• AVOID with PPIs

Citrate = 21% elemental

Max absorption = 600mg

Question 2

Bisphosphonates

Answer 2

Alendronate (Fosamax)
Risedronate (Actonel / Altevia)
Ibandronate (Boniva)

Zoledronic Acid (Reclast) = IV
(Zometa = malignancy)

Question 3

Bisphosphonates ADRs

Answer 3

1) Hypocalcemia
2) ONJ

Altevia (Risedronate) CI w/ acid-suppressing drugs

Question 4

SERMs

Answer 4

Raloxifene (Evista)
- Ppx of Postmenopause osteoporosis + breast cancer

Conjugated Estrogens + Bazedoxifene (Duavee)

• WITH a UTERUS
• increases Breast Cancer risk

Question 5

Denosumab

Answer 5

[Prolia]
[Xgeva] = malignancy

ADR: HYPO-calcemia

Question 6

Teriparatide (Forteo)

Answer 6

ADR: HYPER-calcemia