Other High Glucose States Flashcards Preview

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Flashcards in Other High Glucose States Deck (11):
1

How is lactate produced?

Glucose
Pyruvate and NADH
(anaerobic conditions)
Lactate and NAD+

2

Where in the cell is lactate produced?

cytoplasm

3

Why does type A lactic acidosis occur?

hypoxameia

4

When does type B lactic acidosis occur?

Liver disease
Metformin reaction
Diabetes

5

What are the symptoms of lactic acidosis?

Hyperventilation
Confusion
Stupor/coma

6

What happens to
A) bicarbonate
B) glucose
C) ketones
D) phosphate in lactic acidosis?

A) Raised
B) Raised
C) Absent
D) Raised

7

What is the equation to work out the anion gap?

(Na+ + K+) - (HCO3- + Cl-)

8

What happens to the anion gap in lactic acidosis?

High anion gap

9

Where is lactate produced?

Red cells
Skeletal muscle
Brain
Renal medulla

10

How is lactate cleared?

Uptake by liver
Aerobically converted
pyruvate then glucose

11

How is lactic acidosis treated?

Fluids
Antibiotic if needed
Stop underlying cause