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Flashcards in Page 210 Deck (21)
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1

Epoetin alfa (erythropoietin)

Clinical uses

Anemias (especially in renal failure)

2

Thrombopoietin

Clinical uses

Thrombocytopenia

3

Oprelvekin (interleukin-11)

Clinical uses

Thrombocytopenia

4

Filgrastim (granulocyte colony-stimulating factor)

Clinical uses

Recovery of bone marrow

5

Sargramostim (granulocyte-macrophage colony-stimulating factor)

Clinical uses

Recovery of bone marrow

6

Aldesleukin (interleukin-2)

Clinical uses

Renal cell carcinoma, metastatic melanoma

7

IFN-α

Clinical uses

Chronic hepatitis B and C, Kaposi sarcoma, hairy cell leukemia, condyloma acuminatum, renal cell carcinoma, malignant melanoma

8

IFN-β

Clinical uses

Multiple sclerosis

9

IFN-γ

Clinical uses

Chronic granulomatous disease

10

Alemtuzumab

Target/clinical use

CD52

CLL
“Alymtuzumab”—chronic lymphocytic leukemia

11

Bevacizumab

Target/clinical use

VEGF

Colorectal cancer, renal cell carcinoma

12

Cetuximab EGFR

Target/clinical use

Stage IV colorectal cancer, head and neck cancer

13

Rituximab

Target/clinical use

CD20

B-cell non-Hodgkin lymphoma, rheumatoid arthritis (with MTX), ITP

14

Trastuzumab

Target/clinical use

HER2/neu

Breast cancer, gastric cancer

HER2—“tras2zumab”

15

Infliximab, adalimumab

Target/clinical use

TNF-α

IBD, rheumatoid arthritis, ankylosing spondylitis, psoriasis

Rheumatoid arthritis “inflix” pain in “da limbs”

16

Natalizumab

Target/clinical use

α4-integrin

Multiple sclerosis, Crohn disease


α4-integrin: leukocyte adhesion
Risk of PML in patients with JC virus

17

Abciximab

Target/clinical use

Glycoprotein IIb/IIIa

Anti-platelet agent for prevention of ischemic complications in patients undergoing percutaneous coronary intervention

IIb times IIIa equals
“absiximab”

18

Denosumab

Target/clinical use

RANKL

Osteoporosis; inhibits osteoclast maturation (mimics osteoprotegrin)

Denosumab affects osteoclasts

19

Digoxin immune Fab

Target/clinical use

Digoxin

Antidote for digoxin toxicity

20

Omalizumab

Target/clinical use

IgE

Allergic asthma; prevents IgE binding to FcεRI

21

Palivizumab

Target/clinical use

RSV F protein

RSV prophylaxis for high-risk infants

PaliVIzumab—VIrus