Rate-determining enzymes (pg 97) Flashcards Preview

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Flashcards in Rate-determining enzymes (pg 97) Deck (13)
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1

Glycolysis

Enzyme/Regulators

Phosphofructokinase-1 (PFK-1)

AMP +, fructose-2,6-bisphosphate +
ATP -, citrate -

2

Gluconeogenesis

Enzyme/Regulators

Fructose-1,6-bisphosphatase

ATP +, acetyl-CoA +
AMP -, fructose-2,6-bisphosphate -

3

TCA cycle

Enzyme/Regulators

Isocitrate dehydrogenase


ADP +
ATP -, NADH -

4

Glycogenesis

Enzyme/Regulators

Glycogen synthase

Glucose-6-phosphate +, insulin +, cortisol +
Epinephrine -, glucagon -

5

Glycogenolysis

Enzyme/Regulators

Glycogen phosphorylase


Epinephrine +, glucagon +, AMP +
Glucose-6-phosphate -, insulin -, ATP-

6

HMP shunt

Enzyme/Regulators

Glucose-6-phosphate dehydrogenase (G6PD)

NADP+ +
NADPH -

7

De novo pyrimidine synthesis

Enzyme/Regulators

Carbamoyl phosphate synthetase II

8

De novo purine synthesis

Enzyme/Regulators

Glutamine-phosphoribosylpyrophosphate (PRPP) amidotransferase


AMP -, inosine monophosphate (IMP) -, GMP -

9

Urea cycle

Enzyme/Regulators

Carbamoyl phosphate synthetase I

N-acetylglutamate +

10

Fatty acid synthesis

Enzyme/Regulators

Acetyl-CoA carboxylase (ACC)

Insulin +, citrate +
Glucagon -, palmitoyl-CoA -

11

Fatty acid oxidation

Enzyme/Regulators

Carnitine acyltransferase I

Malonyl-CoA -

12

Ketogenesis

Enzyme/Regulators

HMG-CoA synthase

13

Cholesterol synthesis

Enzyme/Regulators

HMG-CoA reductase


Insulin +, thyroxine +
Glucagon -, cholesterol -