Pancrease glucose regulation Flashcards
(29 cards)
Islets of langerhans
endocrine
Insulin
glucagon
somatostatin
Pancreatic Acinar cells
Exocrin cells
Digestive enzymes
bicarbonate
Enzymes
Pancreatic amylase Tripsin chymotropine elastase Pancreatic lipase Ribonuclease Deoxyribonulease
What stimulates exocrine secretion
Parasympathetic NA
Secretin
Cholecystokinin CKK
What does Cholecystokinin do
From intestinal mucosa
* stimulates digestive enzyme secretion in the pancreas
What does secretin do
Secretin is released when acid enters duodenum causing the bicarbonate secretion from pancreas
Secretin secretes what
bicarbonate
What stimulates exocrine secretion
Secretin (acid)
CCK (Protein and fat)
What does islets of Langerhands have?
Alpha cells: 15-20% Beta Cells: 65-80% Delta Cells: 3-10% PP cells: 3-5% Epsilon Cells: <1%
Alpha cells
Glucagon: promotes glycogenolysis
CCK and ACH stimulates
Beta cells
Insulin: decrease serum insulin
C peptide
amylin: slow gastric empty, satiety
Delta cells
Somatostatin:
Inhibit alpha and beta cells
supresses other GI hormones
PP cells
pancreatic polypeptide: Regulate pancreatic secretions
Epsilon cells
Grehelin: Increases hunger
What inhibits Glucagon
Somatostatin (delta cells)
insulin (beta cells)
Insulin
regulates metabolism of carbohydrats an dats by promoting absorption from the blood into myocytes and adipose
Fat storage
Sub Qutaneous
C-Peptide is waht
when proinsulin in chopped into insulin
Inhibit insulin
Epi and nore epi
glucagon
Release insulin
Acetylcholine
Cholecystokinin
GI: GLP-1, GIP
Insulin release oscilates
3-6min
What are most influenced by insulin
Myocytes
Adipose
What happens when blood glucsoe falls
glucagon and catecholamines are released to stimulate glycogenolysis, gluconeogenesis
PCOS
anovulation
androgen excess
insulin resistence
Where do insulinomas come from
Beta cells: secret insulin
