Part 1 Flashcards
Which drugs are the drugs of choice for the relief of neuropathic pain?
Tricyclic antidepressants and antiepileptic drugs
Which NSAID has the highest risk of gastropathy?
Ketorolac
Please list the general principles of rational pharmacotherapy of pain
All —> 1 stepwise increase in strength of meds
2 clockwise basis and at a regular dose
3 per Oral formulations
4 Individualised
5 For a limited time
COX-2 inhibitors are contraindicated in patients
patients with stroke
ischemic heart disease
Which oral NSAID has the highest risk of thrombosis adverse drug reaction?
Etoricoxib 120mg
Basic principles of rational pharmacotherapy of pain with narcotic analgesics
ALL
used in cases when the treatment with other medications are insufficient
Short-acting preparations replaced by long acting after 1-2 weeks
the dose titration is up to 1-2 weeks
treatment should be continued for up 4-6 weeks
Combinations of opioids with paracetamol or ibuprofen
What safety test to be performed for glucocorticoid pulse therapy?
Glucose test, Monitoring for possible hypertension
Is it rational to use combination of paracetamol and narcotic analgesics for pain relieve?
Rational combination due to more potential analgesic effect,
Rational due to reduction in dose of narcotic analgesics and lower risk of adverse drug reactions
What is the strategy in case of suspected paracetamol overdose?
Urgent administration of the antidote N-acetylcysteine
Which are the drugs of choice for the treatment of musculoskeletal pain, dysmenorrhoea and tension headache?
Paracetamol, ibuprofen, naproxen
Which nitroglycerin pharmaceutical formulation has the longest duration of action?
Transdermal
Which statement describes tolerance to nitrates?
24 hrs continuous therapy with nitrates rapidly produces tolerance along with loss of antianginal, and antiischemic effects.
What safety tests are mandatory to prevent statin side effects?
Creatine phosphokinase test, Liver enzymes test
Which beta-adrenoceptor blocker has the highest lipophilic factor?
Propranolol
What safety test are mandatory for the prevention of beta-blockers adverse drug reactions?
Monitoring of heart rate (HR) for bradycardia, ECG for conduction abnormalities,, bronchospasm, Blood glucose test
The effectiveness of statins should be evaluated
3-4 weeks after starting statin therapy
Which nitroglycerin formulation has the fastest onset of action?
Sublingual
What safety test are mandatory to prevent ACE inhibitor side effects?
Monitoring of dry cough, Potassium, Kidney function test, BP for possible hypotension
Please select medicines for the initial treatment of most hypertensive patients in the absence of other concomitant diseases
Calcium channel blockers, ACE inhibitors/sartans, Thiazide duretics
Which pharmacotherapy group has the most potential effect on reduction of total plasma cholesterol and low-density lipoprotein?
Statins
patient has hypertension and Parkinson disease which are managed by valsartan and trihexyphenidyl, omperazole and lorazepam. Patient falls due to
orthostatic hypotension (lorazepam increased the effect of valsartan)
Parkinsonism due previously used haloperidol. Whic drugs are suitable to treat this adverse drug reaction?
trihexyphenidyl, amantadine
What interaction can occur when amitriptyline and clemastine are used concomitantly?
increased anticholinergic effect and sedation
What adverse effects can be caused by tricyclic antidepressants?
Brugada syndrome and orthostatic hypotension
