Part 3 Flashcards
What interaction can be expected when metoprolol and amiodarone are used concomitantly?
Bradycardia, hypotension, Atriovantricular block
Which of the following antiarrhythmics increases mortality if it is used longterm?
Digoxin
What interaction can be expected when amiodarone and propafenone are used concomitantly?
atrioventricular blockage
Which drug should be recommended for the patient with tachysystolic permanent atrial fibrillation and heart failure, if previously used beta blockers and calcium channel blockers were ineffective?
Digoxin
Which of the following does notoes not signicantly lower heart rate?
lidocaine
The patients takes haloperidol. What antiarrhythmic drugs should not be prescribed for this patient?
Quinidine, Amiodarone
Which of the following should not not be used after myocardial infarction?
propafenone
Which of the following is contraindicated in case of allergy to iodine?
Amiodarone
What interaction can be expected when amiodarone and uconazole are used concomitantly?
QTc prolongation and polymorphic paroxysmal ventricular tachycardia
The patient takes amiodarone, doxazosine and fosinopril. He was diagnosed with Lyme disease. What antibacterial agent should be prescribed to treat Lyme disease?
Cefuroxime
In which of the situations differences in ecacy are possible due to pharmacokinetic peculiarities of In which of the situations differences in ecacy are possible due to pharmacokinetic peculiarities of medicine
Appears after interchange of one prolonged release insulin into another prolonged release insulin,
Appears after deterioration of liver function,
Appears after deterioration of kidney function
In case of renal failure
Nephrotoxic medicines are avoidable,
Dosages of medicines eliminated through kidneys are NOT always corrected
In which of the cases of treatment we can-not conclude the rationality of the treatment
None of the answers is correct
When do we need to assess whether treatment is rational
All answers are correct
Example of adverse drug reaction type C
Hyperglycaemia due to steroids
In which of the situations differences in efficacy or safety are possible due to pharmacotherapeutic peculiarities of medicine
All answers are correct
Pharmacogenetics might influence
The pharmacokinetic and/or pharmacodynamic of the medicine
Drug interaction can be caused by
Food, Haemodialysis
What provisions of authorization denes safety of medicine?
ALL
Summary of Product Characteristics (SmPC) Section 4.2, Section 4.3, Section 4.4
What does it mean to use medicine based on approved indication?
Administer medicine based on SmPC Sections 4.1 and 4.2
Define the precision of antimicrobial spectrum
Empiric treatment (or prophylaxis) is directed towards MOST possible infectious agent
Which of the antimicrobial treatments is most rational
Targeted treatment that is guided by species of infectious agent and its sensitivity based on MIC
Define rationality of more convenient but more expensive antimicrobial treatment
More expensive antimicrobials might be rational, provided lead to essentially better compliance with therapy
What is the determinant of gentamicin safety, provided minimal inhibitory concentration (MIC) of infectious agent is known
How much concentration is above minimally safe concentration
