Part 2

Question 1

Which dose of aspirin is suitable for prevention of ischaemic stroke?

Answer 1

100mg

Question 2

Which of the following can decrease the effect of clopidogrel?

Answer 2

omeprazole

Question 3

What laboratory tests should be monitored if the patient takes apixaban for the prevention of stroke?

Answer 3

No specic tests are necessary

Question 4

Which of the following are contraindications for the use of warfarin?

Answer 4

Unable to monitor INR
Recent bleeding in colon cancer

Question 5

Which of the following INR level shows that the effect of warfarin was insufficient

Answer 5

1.6-1.9

Question 6

The correct answers are: 14 days before initiation of rasagiline, uoxetine should be discontin

Answer 6

Spironolactone

Question 7

What laboratory tests should be monitored if the patient takes ticagrelor?

Answer 7

Monitoring of APTT and INR is not required

Question 8

How long does the action of clopidogrel last after its discontinuation?

Answer 8

5-7 days

Question 9

Signs and characteristics of heparin-induced type II (autoimmune) thrombocytopenia?

Answer 9

All

severe thrombocytopenia, APTT returns to normal range while on heparin therapy, Thrombocytopenia typically occurs when heparin is administeresd for 5-20 days, Thromboses and embolism occur

Question 10

How should switching from heparin to dabigatran be done?

Answer 10

dabigatran should be initiated next day after discontinuation of heparin

Question 11

What lab tests or other parameters should be monitored on the regular basis if the patient uses sodium valproate?

Answer 11

blood alanine transaminase and aspartate transaminase levels (ALT, AST)

Question 12

Which of the following statement about any of two antiepileptic drugs used concomitantly is correct?

Answer 12

the treatment effect increases minimally, but the adverse effects become more common

Question 13

Which of the following is considered the contraindication for sumatriptan?

Answer 13

Myocardial infarction

Question 14

What can occur if trihexyphenidyl and antipsychotics are used concomitantly?

Answer 14

tachycardia

Question 15

The patient has been taking uoxetine and levodopa/carbidopa for several months. Because of “on-off” syndrome, the physician decided to add rasagiline. Which of the following statements are correct?

Answer 15

14 days before initiation of rasagiline, uoxetine should be discontinued, Concomitant use of rasagiline and uoxetine may result in serotoninergic syndrome

Question 16

65 years old patient experienced migraine attack. She also had ischemic stroke, has Raynaud syndrome and gastric ulcer. What drug is the most suitable to manage migraine attack?

Answer 16

Acetaminophen

Question 17

What effect can result from concomitant use of sumatriptan and sertraline?

Answer 17

serotoninergic syndrome

Question 18

Which drug dose should be reduced signicantly if creatinine clearance is between 30 and 50 ml/min?

Answer 18

amantadine

Question 19

Which of the following statement about carbamazepine is correct?

Answer 19

Carbamazepine is strong izoenzyme 3A4 inducer therefore it can decrease blood levels of other drugs and thus decrease the effect.

Question 20

Which of the following statements about antiepileptic drug polytherapy are correct?

Answer 20

Polytherapy has only minor added benet in terms of improvent of disease control, Polytherapy increases the risk of teratogenicity

Question 21

56 years old patient has type 2 diabetes, renal failure and grade III obesity. Creatinine clearance is 20 ml/mi. What drug would you recommend for this patient?

Answer 21

Insulin

Question 22

72 years old patient has type 2 diabetes, stage C heart failure. His creatinine clearance is 75 ml/min. Which of the following should not not be use for this patient?

Answer 22

pioglitazone

Question 23

Which of the following antihypertensives could be used to prevent possible interaction with glibenclamid?

Answer 23

amlodipine

Question 24

The patient with hyperthyroidism became pregnant. Which of the following drugs can be used to treat hyperthyroidism in this case?

Answer 24

Propylthiouracil

Question 25

What are possible interactions between levothyroxine and metformin?

Answer 25

Falsely reduce TSH levels while T4 remains unchanged, Decreased metformin effect

Question 26

Patient suffers form mild GERD, renal failure, hypertension and stable angina. takes fosinopril, metoprolol, ranitidine and clopidogrel. Which of these drugs could cause psychosis?

Answer 26

ranitidine

Question 27

The patient has type 2 diabetes, heart failure and hypertension. He takes gliclazide, ramipril, amlodipine and indapamide. The patient has experienced hypoglycemia. Could this be due to interaction between gliclazide and other drugs?

Answer 27

Yes, due interaction with ramipril

Question 28

The patient with diabetes, hypothyroidism and hypertension uses levothyroxine, ramipril, indapamide and metformin. The patient developed extrasystoles, tremor, anxiety, insomnia, cramps, weight loss and diarrhea. Which drug overdosage could have resulted in these symptoms?

Answer 28

levothyroxine

Question 29

Proton pump inhibitors increase gastric pH. How can this affect the absorption of various drugs?

Answer 29

ALL The absorption can be increased, The absorption can be decreased, The absorption can remain unchanged

Question 30

75 years old patient has type 2 diabetes, and chronic obstructive pulmonary disease. The patient takes metformin, inhales fluticasone, salmeterol, and tiotropium bromide. Could any of the following drugs be associated with ineffective treatment of diabetes mellitus?

Answer 30

Fluticasone