Sample 2:1 Flashcards
What safety tests should be performed for oral glucocorticoids long-term therapy?
Monitoring of gastrointestinal adverse drug reactions, Peripheral blood glucose test
Blood lipid profile test
Please name the main directions of future of pain pharmacotherapy
Development of new pharmaceutical formulations of analgesics, Stem cell preparations, Development of new pain mechanisms/receptors
What is the use of hydrocortisone replacement therapy?
To reduce hypothalami-pituitary-adrenal suppression in stressful situations during long-term glucocorticoid therapy
Please state correct indication for the use of nimesulide?
A secondary medicine if other medicines are ineffective and only in the presence of acute or dysmenorrheal pain for up to 15 days
Which oral NSAID has the highest risk of hepatic adverse drug reactions?
Nimesulide 100mg
The analgesic effect of NSAIDs depends on
General analgesic potency depends on NSAID dose
What is the most common adverse drug reaction of vasoselective calcium channel blockers?
Peripheral edema - “ankle edema”
Which calcium channel blocker has cardio depressive action?
Verapamil
What safety test are mandatory to prevent ACE inhibitor side effects?
Monitoring of dry cough, Potassium test in the blood, Kidney function test, Monitoring of blood pressure for possible hypotension
What safety tests are mandatory to prevent statin side effects?
Creatine phosphokinase test, Liver enzymes test
Which calcium channel blocker is vasoselective?
Amlodipine
What adverse effect can be caused by long term use of antipsychotics?
dyskinesia and dystonia
Which of the following bezodiazepine can be used for anaesthesia induction?
midazolam
Which benzodiazepines should not be recommended for the older patient?
diazepam, clonazepam
What interaction can occur when amitriptyline and clemastine are used concomitantly?
increased anticholinergic effect and sedation
Which of the following drugs can cause psychosis?
dopamine receptor agonists, MAO inhibitors and sympathomimetics
Which of the following drug effect can be increased by benzodiazepines?
amlodipine
Which of the following antidepressants are considered least sedative?
sertraline and citalopram
Which of the following best describes “atypical” antipsychotics?
They rarely cause extra pyramidal effects and are more suitable to treat negative symptoms of schizophrenia
Which classes of antidepressants are associated with increased risk of sudden death due to possible arrthythmias?
tricyclic antidepressants, Some SSRIs
Which of the following drugs can decrease the effect of clopidogrel?
fluconazole, clarythromycin
Which drug increases the risk of hyperkalaemia when used concomitantly with heparin?
perindopril
How should the switching from rivaroxaban to warfarin be done?
Rivaroxaban and warfarin used concomitantly until INR is more than 2, then rivaroxaban can be discontinued.
Which of the following can decrease the effect of warfarin?
spironolactone, carbamazepine
