Sample 2:3 Flashcards
76 years old patient was prescribed clarithromycin, ramipril and amlodipine. ECG revealed the prolonged QTc interval (560 ms). Why?
Because of amiodarone and clarithromycin interaction
What CANNOT be used to treat supraventricular extrasystoles?
adenosine
Which of the following can increase blood digoxin level?
P-gp inhibitors
Which drug of the following requires thyroid function monitoring?
amiodarone
Most suitable to treat ventricular extrasystoles?
Propranolol
What interaction can be expected when amiodarone and fluconazole are used concomitantly?
QTc prolongation and polymorphic paroxysmal ventricular tachycardia
Risk factors of NSAID gastrointestinal adverse drug reactions are as follows
All
Young pts, H. Pylori infection, High dose NSAIDs, Combinations of NSAIDs with aspirin or glucocorticoids, Older pts
Conditions of local use of NSAIDs formulations
Mild to moderate regional pain, Poly-pharmacy and increased risk of adverse drug interactions
Patient taking valsartan, trihexyphenidyl, omperazole and lorazepam. Fell trying to stand up from lying down.
orthostatic hypotension (lorazepam increased the effect of valsartan)
Adverse effects of alprazolam used to treat insomnia?
suicidal behaviour, memory disorders
Which of the following is considered the most suitable to treat panic attacks?
diazepam
45 years old using amlodipine and venlafaxine, sertraline. After several days patient developed diarrhea, became anxious, irritable, she complained about insomnia, blood pressure became unstable - increased and decreased. How can these symptoms be explained?
Interaction between venlafaxine and sertraline resulted in serotoninergic syndrome
Most suitable for long term stroke prophylaxis, if the patient does not have permanent atrial fibrillation?
Aspirin
The patient takes dabigatran. What drug should be administered in case of life-threatening bleeding?
idarucizumab
PT on warfarin therapy. Which INR level shows that the effect of warfarin was insufficient?
1.6-1.9
PT takes pramipexole, metoprolol, valsartan and torsemide. PT became disorientated, aggressive and developed halluciantions. Which of these drugs could cause such symptoms?
pramipexole
What other disease can be treated with anticonvulsants?
trigeminal neuralgia
What occurs if trihexyphenidyl and antipsychotics are used concomitantly?
tachycardia
The patient has to take omeprazole for several months. Monitoring of
CBC due to possible megaloblastic anemia, blood magnesium levels
The breastfeeding woman has to take propafenone for her arrhythmia.
Discontinue breastfeeding
76 years old man has used amiodarone, QTc interval was 540 ms. potassium level - 3.0 mmol/l, magnesium level - 0.65 mmol/l, sodium level - 129 mmol/l. Why did the QTc interval prolong?
Because of amiodarone and ciprofloxacin interaction, Because of hypokalemia,
Because of hypomagnesemia
