part 3

Question 1

How long and what are the drugs of the initial phase of TB?

Answer 1

-3 months 
(RIPE) 
-Isoniazid 
-rifampin 
-pyrazinamide 
-Ethambutol

Question 2

What are the 2 phases for the drug treatment of TB?

Answer 2

initial and continuation

Question 3

For how long and what are the drugs for the continuation phase?

Answer 3

• 18 weeks
• rifampin
• isoniazid

Question 4

All the medications for TB are hepatotoxic. Which is the least hepatotoxic?

Answer 4

rifampin

Question 5

Which TB medication causes red/orange urine, sweat, tears, and sputum?

Answer 5

rifampin

Question 6

What is DOT therapy and why is it used for a pt with TB?

Answer 6

• Direct observation therapy
• someone brings the pt the medication and watches them take it
• ensures adherence

Question 7

Because the medications for TB are commonly hepatotoxic what labs need to be monitored?

Answer 7

-monitor LFT’s

Question 8

How many medications are needed for latent TB?

Answer 8

• 1 drug
• daily isoniazid
• 9 months
• or isoniazid and rifapentine for 3 month is an option

Question 9

• primary agent
• suppresses bacterial growth
• excreted in urine (may become toxic if poor renal function)
• active LTBI
• take on empty stomach (1 hour before or 2 hours after a meal)

Answer 9

first line drug Isoniazid

Question 10

What types of drugs are of concern if combined with isoniazid?

Answer 10

benzo’s and phenytoin

Question 11

What are some adverse effects of Isoniazid?

Answer 11

peripheral neuropathy
hepatitis
decreased B6 absorption
hepatotoxicity