part 4 Flashcards
(11 cards)
1
Q
- broad spectrum antibiotic
- suppresses RNA synthesis and consequently protein synthesis
- well absorbed on empty stomach
- hepatic metabolism
A
Rifampin
2
Q
- hepatotoxicity is rare
- red/orange bodily secretions
- increases metabolism
- causes hepatitis
- GI disturbances
A
AE of Rifampin
3
Q
- bactericidal to TB
- well absorbed
- excretion is renal
- hepatotoxic
A
Pyrazinamide
4
Q
What is the most toxic of all the initial drugs for TB?
A
Pyrazinamide
-monitor AST and ALT
5
Q
What are the AE for Pyrazinamide?
A
- hepatitis
- most toxic monitor ALT and AST
- gouty arthritis (hyperuricemia)
6
Q
What are the signs and symptoms of hepatitis we need to teach patients when taking the meds for TB?
A
fatigue
loss of appetite
abd pain
7
Q
- bacteriostatic
- used as initial treatment or for thoes who recieved treatment before
A
ethambutol
8
Q
What are the AE of ethambutol?
A
-vision problems and GI
9
Q
How can resistance of TB be prevented?
A
initial therapy should consist of at least 2 but preferably 4 medications
10
Q
How long can the therapy for TB last?
A
6 months to 2 years
11
Q
How can patient adherence to med therapy for TB be greatly increased?
A
DOT therapy combined with intermittent rather than daily dosing
