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Flashcards in Path Bleeding disorders Deck (26):
1

overproduction of corticosteroids from adrenal
cortex

Cushing’s Syndrome brittle blood vessels, severe osteoporosis, obesity, diabetes,high BP

2

o Prolonged steroid medication use can have symptoms similar to

Cushing’s, easy bruising

3

bruises > 2 cm

Ecchymoses

4

– larger than a pinpoint, but < 2 cm

Purpura

5

– leak of blood into cavities o

Hematoma

6

Rupture of middle meningeal artery

epidural hematoma

7

Thrombocytopenia

Normal amount of platelets in blood: 250,000 – 300,000

< 140,000 = prone to hemorrhage

Petechial or purpural rashes are typical—needs to be less than 2 cm

8

no platelet activation  cannot form platelet plug

hemorrhagic gastroduodenitis--- balck stool

 Von Willebrand’s Disease

9

– increased amount of blood lost during menstruation

menorrhagia (related to von willebrand's)

10

serious
disorder manifested usually from uterus cancer, which results in
loss of blood between menstruation periods

metrorrhagia/not related to Von W

11

non-production of certain protein clotting factors

Hemophilia

12

Hemophilia genetics

mother to son X chromosome (skips a generation)

13

nonproduction of CF 8 viii

Hemophilia A

14

nonproduction of CF 9

Christmas disease/Hemophilia B

15

Hemoarthritis

Trauma leads to blood in joint spaces, esp. Knee joint

Iron released from heme into blood destroys the joint cartilage

16

Hemodynamic Disorders

 Disorders that arise from interruptions in normal blood flow

17

platelet activation and platelet aggregation
without threat of blood loss or vascular damage; platelet plug without blood clot

Thrombosis

18

always originates from a vascular wall and always maintains point of contact with the vascular wall through von Willebrand factorplatelet
activaton and platelet aggregation

Thrombus

19

Thrombus in the arterial system

Dense and strong , firm and small (fast)

20

Thrombus in the venous system

Loose and weak , loose and large (slow)

21

represent a special type of thrombi characterized by visible and
microscopic laminations produced by alternating layers: pale layer composed of
platelets mixed with fibrin and dark layer composed of RBCs

Lines of Zahn

22

lines of Zahn + thrombi can be found

heart/aorta(mitral stenosis)

23

factors predisposing to thrombosis

Endothelial damage
Hypertension- increase resistance of the vascular wall to the fluid. Serious factor
that promotes endothelial damage.

24

Iatrogenic thrombosis

medically induces endothelial damage via syringes.

25

Decreased rate of flow causes a disruption in axial blood flow by

platelets flow closer to the vessel wall

26

decreased rate of blood flow caused by

cardiac damage
increased blood viscosity