Flashcards in Pathogens Host Defenses Deck (103)
What are the chemical properties of endotoxins?
Lipopolysaccharide-lipoprotein complexes, released on cell lysis as part of the outer membrane of gram-negative bacteria; extremely heat-stable
What is the mode of action/symptoms of exotoxins?
Specific; usually binds to specific cell receptors or structures; either cytoyoxin, enterotoxin or neurotoxin with defined, specific action on cells or tissues
What is the mode of action/symptoms of endotoxins?
General; fever, diarrhea, vomiting
What is the toxicity of exotoxins?
Often highly toxic, sometimes fetal
What is the toxicity of endotoxins?
Weakly toxic, rarely fatal
What is the immunogenicity response of exotoxins?
Highyl immunogenic; stimulate the production of neutralizing antibody (antitoxin)
What is the immunogenicity response of endotoxins?
Relatively poor immunogen; immune response not sufficient to neutralize toxin
What is the toxoid potential of exotoxins?
Treatment of toxin with formaldehyde will destroy toxicity, but treated toxin (toxoid) remains immunogenic
What is the toxoid potential of endotoxins?
What is the fever potential of exotoxins?
Does not produce fever in host
What is the fever potential of endotoxins?
Pyrogenic (heat), often induces fever in host
What are pathogenicity islands?
the section of the chromosome encoding virulence factors