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Flashcards in Pathogens Host Defenses Deck (103)
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91

What are the chemical properties of endotoxins?

Lipopolysaccharide-lipoprotein complexes, released on cell lysis as part of the outer membrane of gram-negative bacteria; extremely heat-stable

92

What is the mode of action/symptoms of exotoxins?

Specific; usually binds to specific cell receptors or structures; either cytoyoxin, enterotoxin or neurotoxin with defined, specific action on cells or tissues

93

What is the mode of action/symptoms of endotoxins?

General; fever, diarrhea, vomiting

94

What is the toxicity of exotoxins?

Often highly toxic, sometimes fetal

95

What is the toxicity of endotoxins?

Weakly toxic, rarely fatal

96

What is the immunogenicity response of exotoxins?

Highyl immunogenic; stimulate the production of neutralizing antibody (antitoxin)

97

What is the immunogenicity response of endotoxins?

Relatively poor immunogen; immune response not sufficient to neutralize toxin

98

What is the toxoid potential of exotoxins?

Treatment of toxin with formaldehyde will destroy toxicity, but treated toxin (toxoid) remains immunogenic

99

What is the toxoid potential of endotoxins?

None

100

What is the fever potential of exotoxins?

Does not produce fever in host

101

What is the fever potential of endotoxins?

Pyrogenic (heat), often induces fever in host

102

What are pathogenicity islands?

the section of the chromosome encoding virulence factors

103

Slide 26

Host defenses