Pathology of MSK

Question 1

What are the four functional purposes of hyaline cartilage at synovial joints?

Question 2

Which joints are usually spared of OA?

Answer 2

Wrist, elbows, shoulders

Question 3

What are the earlier and later changes of OA pathology?

Answer 3

Early:

Small cartilage fissures
Fibrillation

Late:
Erosion/Eburnation (reactive conversion)

Question 4

What are the radiological correlations of (4 characteristics)?

Question 5

What are the clinical correlations of osteophytes/other pathological changes?

Question 6

What joints are more likely to be affected in RA and which joints are spared?

Answer 6

More affected: start with small joints (hands and feet)

Sparing hips and lumbosacral joints (which are very likely to be affected in OA)

Question 7

What are presentations in acute phase in RA? and chronic phase?

Answer 7

Acute:
Pannus formation

Question 8

What is Paget’s disease of bones? What are the three stages?

Question 9

Which bones are more commonly affected in Paget’s?

Answer 9

Usually axial, small bones less commonly affected