Pathoma: 2a hemostatsis and related disorders Flashcards Preview

Unit 4: Blood and Lymph > Pathoma: 2a hemostatsis and related disorders > Flashcards

Flashcards in Pathoma: 2a hemostatsis and related disorders Deck (49)
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1

What is the goal of 2a hemostasis?

to stabilize the platelet plug

2

How does 2a hemostasis achieve its end goal?

via the coagulation cascade

3

What is the receptor for platelet aggregation?

GPIIb/IIIa

4

What molecule links the platelets via GPIIb/IIIa?

fibrin

5

What is the end product of the coagulation cascade?

thrombin

6

What does thrombin do?

it converts fibrinogen to fibrin

7

What gets crosslinked to generate a stable platelet plug?

fibrin

8

What 3 things does activation require?

1. exposure to an activating surface
2. phospholipid surface
3. calcium

9

Where does the calcium come from?

dense platelet granules

10

In general, a disorder of 2a hemostasis is due to _____.

factor abnormalities

11

______ is the major clinical feature of 2a hemostasis.

Deep bleeding (into muscles and joints) and rebleeding after surgery

12

In 1a hemostasis, the primary problem is ______.

superficial bleeding (into mucosa and

13

What is the PT test?

a measure of extrinsic and common factors

14

What is the PTT test?

a measure of intrinsic and common factors

15

What is the order of the intrinsic pathway factors, ending at 10?

12, 11, 9, 8, 10

16

What is the order of the intrinsic pathway factors, ending at 10?

7, 10

17

What is the order of the common pathway, starting at 10?

10, 5, 2, 1

18

What activates factor 12 (the intrinsic pathway)?

subendothelial collagen (SEC)
* PTT and SEC are both 3 letters

19

What activates factor 7 (the extrinsic pathway)?

tissue thromboplastin (TT)
* TT and PT are both 2 letters

20

Which test is better for measuring heparin?

PTT
* PTT and HEP are both 3 letters

21

Which test is better for measuring warfarin/Coumadin?

PT

22

What is hemophilia A?

an X-linked defect of factor VIII (8)
* hemophilia AAAAA-eight

23

How do hemophilia A pts present?

deep tissue, joint, and post-surg bleeding

24

The clinical severity of hemophilia A depends on _____.

the degree of deficiency

25

Hemophilia A lab results?

increased PTT
normal PT
decreased FVIII
normal platelets
normal bleeding time

26

What is the treatment for Hemophilia A?

give recombinant factor VIII

27

What is Hemophilia B?

a genetic factor IX (9) deficiency

28

What is another name for Hemophilia B?

Christmas disease

29

What is a coagulation factor inhibitor?

an autoantibody against a coagulation factor, impairing its function

30

Which factor is commonly targeted by coagulation factor inhibitors?

factor VIII (8)