Rheumatology: Vasculitis Flashcards Preview

Unit 4: Blood and Lymph > Rheumatology: Vasculitis > Flashcards

Flashcards in Rheumatology: Vasculitis Deck (52)
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1

The vasculitides are a heterogeneous group of clinical disorders characterized by ______.

inflammation of blood vessels

2

Vasculitis classification can be based on ____, ____, and ____.

the size of the vessel involved
type of pathologic change in the vessel wall
the clinical presentation

3

Vasculitides can be _____, occurring separately from any known underlying disease, or _____ to infectious disorders such as hepatitis B or C and endocarditis, drug hypersensitivity, connective tissue diseases (RA, SLE, Sjögren’s), cryoglobulins, and malignancies.

primary; secondary

4

The Chapel Hill Classification of vasculitis is based largely on _____ involved.

the size of the vessels

5

Large-cell vasculitis can either be ____ or ____.

giant cell arteritis, Takayasu's arteritis

6

What BVs are involved in giant cell arteritis?

temporal arteries, vessels originating from the aortic arch, other arteries (less common)

7

What are the s/s of giant cell arteritis?

temporal headache
jaw claudication
scalp tenderness
visual loss

8

What BVs are involved in Takayasu's arteritis?

aortic arch and its branches (any part of the aorta)

9

What are the s/s of Takayasu's arteritis?

claudication of upper>lower extremities
CNS events
granulomatous panarteritis

10

Medium-vessel vasculitis can be ____ or ____.

polyarteritis nodosa; Kawasaki's disease

11

What BVs are involved in polyarteritis nodosa?

small and medium sized arteries, especially at vessel bifurcations

12

What are the s/s of polyarteritis nodosa?

any organ can be involved, esp skin, joints, peripheral nerves, gut, and kidney

13

What BVs are involved in Kawasaki disease?

small and medium sized arteries

14

What are the s/s of Kawasaki disease?

fever
prominent mucocutaneous changes
cervical lymphadenopathy
polymorphous rash
erythema and edema of hands and feet
desquamation
myocarditis
coronary vasculitis

15

The 2 broad categories of small vessel vasculitis are ____ and ____.

antineutrophil cytoplasmic antibody (ANCA) positive vasculides and antineutrophil cytoplasmic antibody (ANCA) negative vasculitides

16

ANCA positive vasculitides can be?

Granulomatosis with polyangiitis (Wegener’s) aka GPA

Eosinophilic granulomatosis with polyangiitis (Churg-Strauss)

Microscopic polyangiitis (MPA)

17

What arteries does GPA affect?

small and medium-sized arteries

18

Where does GPA manifest?

upper respiratory tract (sinuses)
lungs
kidneys
may affect other organs

19

GPA is usually assoc. with serum _____.

cytoplasmic-ANCA (c-ANCA)

20

Eosinophilic granulomatosis with polyangiitis (Churg-Strauss) affects ____.

small arteries and venules

21

Eosinophilic granulomatosis with polyangiitis (Churg-Strauss) manifests where?

multiorgan involvement:
lungs
skin
peripheral nerves
gut
heart
renal (rare)

22

Microscopic polyangiitis (MPA) affects which BVs?

arterioles, capillaries, and venules

23

What are the s/s of microscopic polyangiitis (MPA)?

pulmonary hemorrhage
glomerulonephritis
palpable purpura
peripheral neuropathy
joint and abdominal pain

24

Serum _____ is common in microscopic polyangiitis (MPA).

perinuclear- ANCA (p-ANCA)

25

Antineutrophil cytoplasmic antibody (ANCA) negative vasculitides can be either ____, ____, or ____.

Henoch-Schönlein Purpura (HSP), Essential cryoglobulinemic vasculitis, or Cutaneous leukocytoclastic angiitis

26

Henoch-Schönlein Purpura (HSP) affects which BVs?

arterioles and venules

27

Essential cryoglobulinemic vasculitis affects which BVs?

small vessels, including glomerulocapillaries

28

Henoch-Schönlein Purpura (HSP) presents as?

palpable purpuric skin lesions in lower extremities
arthritis
abdominal pain
hematuria

29

Essential cryoglobulinemic vasculitis presents as?

purpura
arthralgias
weakness
peripheral neuropathy
Raynaud’s phenomenon
glomerulonephritis
pulmonary hemorrhage

30

Often pts are ____ and _____ positive in essential cryoglobulinemic vasculitis.

rheumatoid factor; hepatitis C antibody