Flashcards in Rheumatology: Vasculitis Deck (52)
The vasculitides are a heterogeneous group of clinical disorders characterized by ______.
inflammation of blood vessels
Vasculitis classification can be based on ____, ____, and ____.
the size of the vessel involved
type of pathologic change in the vessel wall
the clinical presentation
Vasculitides can be _____, occurring separately from any known underlying disease, or _____ to infectious disorders such as hepatitis B or C and endocarditis, drug hypersensitivity, connective tissue diseases (RA, SLE, Sjögren’s), cryoglobulins, and malignancies.
The Chapel Hill Classification of vasculitis is based largely on _____ involved.
the size of the vessels
Large-cell vasculitis can either be ____ or ____.
giant cell arteritis, Takayasu's arteritis
What BVs are involved in giant cell arteritis?
temporal arteries, vessels originating from the aortic arch, other arteries (less common)
What are the s/s of giant cell arteritis?
What BVs are involved in Takayasu's arteritis?
aortic arch and its branches (any part of the aorta)
What are the s/s of Takayasu's arteritis?
claudication of upper>lower extremities
Medium-vessel vasculitis can be ____ or ____.
polyarteritis nodosa; Kawasaki's disease
What BVs are involved in polyarteritis nodosa?
small and medium sized arteries, especially at vessel bifurcations
What are the s/s of polyarteritis nodosa?
any organ can be involved, esp skin, joints, peripheral nerves, gut, and kidney
What BVs are involved in Kawasaki disease?
small and medium sized arteries
What are the s/s of Kawasaki disease?
prominent mucocutaneous changes
erythema and edema of hands and feet
The 2 broad categories of small vessel vasculitis are ____ and ____.
antineutrophil cytoplasmic antibody (ANCA) positive vasculides and antineutrophil cytoplasmic antibody (ANCA) negative vasculitides
ANCA positive vasculitides can be?
Granulomatosis with polyangiitis (Wegener’s) aka GPA
Eosinophilic granulomatosis with polyangiitis (Churg-Strauss)
Microscopic polyangiitis (MPA)
What arteries does GPA affect?
small and medium-sized arteries
Where does GPA manifest?
upper respiratory tract (sinuses)
may affect other organs
GPA is usually assoc. with serum _____.
Eosinophilic granulomatosis with polyangiitis (Churg-Strauss) affects ____.
small arteries and venules
Eosinophilic granulomatosis with polyangiitis (Churg-Strauss) manifests where?
Microscopic polyangiitis (MPA) affects which BVs?
arterioles, capillaries, and venules
What are the s/s of microscopic polyangiitis (MPA)?
joint and abdominal pain
Serum _____ is common in microscopic polyangiitis (MPA).
perinuclear- ANCA (p-ANCA)
Antineutrophil cytoplasmic antibody (ANCA) negative vasculitides can be either ____, ____, or ____.
Henoch-Schönlein Purpura (HSP), Essential cryoglobulinemic vasculitis, or Cutaneous leukocytoclastic angiitis
Henoch-Schönlein Purpura (HSP) affects which BVs?
arterioles and venules
Essential cryoglobulinemic vasculitis affects which BVs?
small vessels, including glomerulocapillaries
Henoch-Schönlein Purpura (HSP) presents as?
palpable purpuric skin lesions in lower extremities
Essential cryoglobulinemic vasculitis presents as?