Flashcards in Pharmacology of Anticoagulation Therapy Deck (7)
What is hemostasis?
the process of clot formation to repair damaged vasculature
What conditions predispose to clot formation?
2. DVT from bed rest, surgery, pregnancy, age, air travel
3. A-fib (blood pools in the atrium)
What are the 3 forms of heparin?
1. unfractionated heparin
2. low molecular weight heparins (LMWH)
3. Fondaparinux (Arixtra)
How do the heparins/oral anticoagulants work?
they interfere with the coagulation cascade and the formation of thrombin
What does thrombin do?
it cleaves fibrinogen into fibrin
What are fibrinolytic agents?
they breakdown clots by increasing plasmin levels