Pathoma- 1a hemostasis and bleeding disorders Flashcards Preview

Unit 4: Blood and Lymph > Pathoma- 1a hemostasis and bleeding disorders > Flashcards

Flashcards in Pathoma- 1a hemostasis and bleeding disorders Deck (74)
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1

What is hemostasis?

repairing damaged blood vessels

2

What is a thrombus?

a clot

3

What is the 1st stage of clot formation?

1a hemostasis

4

What is the goal of 1a hemostasis?

formation of a weak platelet plug

5

What is the goal of 2a hemostasis?

stabilization of platelet plug

6

2a hemostasis is mediated by the _____.

coagulation cascade

7

What is the first step of 1a hemostasis?

rapid, transient vaso-constriction of the damaged BV ("knee-jerk reaction")

8

____ and ____ modulate the first step of 1a hemostasis.

Neurostimulation and endothelien (from the endothelial cells)

9

What is the 2nd step of 1a hemostasis?

Von Willebrand factor lines the damaged area by binding to exposed collagen

10

Why does Von Willebrand factor bind to the damaged vessel?

to allow platelets to bind to them via GPIb receptor

11

Platelets bind to Von Willebrand factor via ____.

GPIb

12

Where does Von Willebrand factor come from?

1. platelets
2. endothelial cells (in the Weible-Palae body)

13

What do Wible-Pilate bodies contain?

P-selectin and Von Willebrand factor

14

What is the 3rd step of 1a hemostasis?

activation of platelets

15

What are the 2 mediators platelets secrete to activate themselves?

1. ADP
2. thromboxane-A2

16

Thromboxane-A2 is a derivative of ____.

platelet cyclooxygenase

17

What kind of granule carries ADP?

dense

18

ADP induces the platelets to express the ____ receptor.

GP2B3A

19

What does GPIIb/IIIa do?

allows the platelets to aggregate to one another

20

Thromboxane-A2 (TXA2) does what?

signals additional platelets to aggregate

21

What is aggregation?

when all the platelets join together at a particular place where initial platelets have adhered

22

What is adhesion?

platelets binding to subendothelial collagen via Von Willebrand factor

23

What is the molecule that links platelets to each other?

fibrinogen

24

Adhesion causes a ____ in platelets and _____, which releases multiple mediators.

shape change; degranulation

25

Platelets aggregate at site of injury via ____ using ____ as a linking molecule.

GpIIb/IIIa; fibrinogen

26

What is the result of 1a hemostasis?

formation of a platelet plug

27

Name the 2 types of general disorders of 1a hemostasis.

1. quantitative
2. qualitative

28

1a disorders of hemostasis are usually due to _____.

abnormalities in platelets

29

When pts have 1a hemostasis platelet disorders, they will classically present with ____ and ____ bleeding.

mucosal; skin

30

What complication can occur with severe thrombocytopenia?

intracranial bleeds