Ped Hem/Onc Kate Flashcards

(56 cards)

0
Q

peripheral pancytopenia w/ hypocellular bone marrow

A

acquired aplastic anemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
1
Q

most common inherited anemia?

A

Congenital Aplastic Anemia- Fanconi anemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

defective DNA repair that is caused by genetic mutation- pancytopenia

A

congenital aplastic anemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

weakness, fatigue, pallor, frequent infections, purpura, petechiae, bleeding, neutropenia, low platelet count

A

acquired aplastic anemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

hx of pica w/ decreased serum ferritin, serum iron, increased TIBC

elevated RDW

A

iron deficiency anemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

megaloblastic anemia finding on peripheral smear

A

hypersegmented neutrophil

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

spherocytes on peripheral smear indicate

A

hereditary spherocytosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

a-thalassemia severity is related to?

A

of gene deletions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

B-minor thalassemia presents?

A

asymptomatic, mild, microcytic hypochromic anemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

B-major thalassemia presents?

A

homozygous for B-globin mutation, early death

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

chronic hemolysis: pallor, fatigue, jaundice, & development of gallstones during childhood & adolescence
Pain due to vaso-occlusion

A

sickle cell

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

labs showing thrombocytopenia and/or neutropenia, followed by progression to pancytopenia

A

congenital aplastic anemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

short stature, cafe-au-lait spots, cephalic issues, developmental delay

A

congenital aplastic anemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

peripheral pancytopenia w/ hypocellular bone marrow

low reticulocyte count

A

acquired aplastic anemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

what is the most common anemia

A

iron deficiency anemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

heinz bodies on peripheral smear?

A

G6PD

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

osmotic fragility test?

A

detects elevated RBC hemolysis

for hereditary spherocytosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

what are the two diagostics for hereditary spherocytosis

A

spherocytes on smear

osmotic fragility test

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

lead poisoning shows what on peripheral smear?

A

basophilic stippling

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

primary polycythemia is

A

congenital erythrocytosis- elevated RBCs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

secondary polycythemia is

A

in response to hypoxemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

most common cause of secondary polycythemia

A

cyanotic congenital heart disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

what is the most common bleeding disorder of childhood

A

idiopathic thrombocytopenic purpura

23
Q

ITP etiology?

A

often follows viral infection

24
most common inherited bleeding disorder?
Von Willibrand disease
25
Petechiae, ecchymosis, epistaxis
ITP
26
hemophilia A is
factor VIII deficiency
27
hemophilia B is
factor IX deficiency
28
which hemophilia is most common
A
29
most common inherited thrombotic condition (in caucasians, anyways)
Leiden mutation
30
palpable purpura on lower extremities, arthralgias, abd. pain, renal disease
Henonch-Schonlein Purpura (HSP)
31
most common small vessel vasculitis
HSP
32
inherited thrombotic disorders (4)
protein C deficiency protein S deficiency antithrombin deficiency Leiden mutation
33
complications of thrombotic disorders
DVT, PE
34
uncontrolled proliferation of immature lymphocytes
ALL
35
complications of tumor lysis syndrome
hyperkalemia hyperuricemia hyperphosphatemia ---> acute renal failure
36
CBC with WBC > 50,000/uL in 20% of pts
ALL
37
25% of pts have WBC > 100,000/uL
AML
38
Auer rods on peripheral smear indicate
AML
39
where will you see blasts on the peripheral smear
ALL & AML
40
Anemia, thrombocytopenia, leukocytosis, relatively few blasts
CML
41
most common solid tumor of childhood
brain tumor
42
most common brain tumor
glial tumor | astrocytomas & ependymomas
43
deadlier, more aggressive brain tumor
medulloblastoma
44
malignant marker cells in Hodgkin Disease?
Reed-Sternberg Cells
45
painless cervical or supraclavicular adenopathy, mediastinal mass, weight loss, fever, night sweats, fatigue, splenomegaly, hepatomegaly
Hodgkin Disease
46
LAD, abd pain, fevers, cough, dyspnea, weight loss, night sweats All developing over 1-3 weeks
Non-Hodgkin Lymphoma
47
most common solid neoplasm outside the CNS
neuroblastoma
48
labs w/ anemia & increased urinary catecholamines
neuroblastoma
49
fever, weight loss, abdominal mass, irritability, bone pain, hematuria, HTN
nephroblastoma
50
nighttime bone pain
Ewing's Sarcoma
51
most common soft tissue sarcoma in kids
rhabdomyosarcoma
52
enlarging abdomen, elevated aFP
hepatic tumor
53
bone tumor that occurs most often in the pelvis, long bones | minority in soft tissue
Ewing's Sarcoma
54
normal platelet count elevated PT, aPTT decreased fibrinogen
liver disease
55
weakness, fatigue, purpura, petechiae, frequent infections, bleeding
acquired aplastic anemia